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Sars1 Gene Detail
Summary
  • Symbol
    Sars1
  • Name
    seryl-tRNA synthetase 1
  • Synonyms
    Sars, Strs
  • Feature Type
    protein coding gene
  • IDs
    MGI:102809
    NCBI Gene: 20226
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108332181-108352525 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    514 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102809
 protein coding gene Chr3:108332180-108352575 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027777
 protein coding gene Chr3:109974532-109996419 (-)
A/J MGP_AJ_G0027737
 protein coding gene Chr3:106487887-106508251 (-)
AKR/J MGP_AKRJ_G0027702
 protein coding gene Chr3:109079083-109099422 (-)
BALB/cJ MGP_BALBcJ_G0027749
 protein coding gene Chr3:106186823-106207183 (-)
C3H/HeJ MGP_C3HHeJ_G0027479
 protein coding gene Chr3:109431311-109452672 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028193
 protein coding gene Chr3:114081543-114101862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025531
 protein coding gene Chr3:102634104-102654721 (-)
CAST/EiJ MGP_CASTEiJ_G0026935
 protein coding gene Chr3:108814599-108834928 (-)
CBA/J MGP_CBAJ_G0027454
 protein coding gene Chr3:117969560-117989864 (-)
DBA/2J MGP_DBA2J_G0027596
 protein coding gene Chr3:105668766-105689051 (-)
FVB/NJ MGP_FVBNJ_G0027564
 protein coding gene Chr3:103553982-103574665 (-)
LP/J MGP_LPJ_G0027703
 protein coding gene Chr3:111393653-111414899 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027594
 protein coding gene Chr3:124013385-124033681 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028248
 protein coding gene Chr3:108678084-108698458 (-)
PWK/PhJ MGP_PWKPhJ_G0026661
 protein coding gene Chr3:105419193-105439874 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026481
 protein coding gene Chr3:106819424-106840704 (-)
WSB/EiJ MGP_WSBEiJ_G0027015
 protein coding gene Chr3:109215533-109235805 (-)



Homology
more
  • Human Ortholog
    SARS1, seryl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SARS1, seryl-tRNA synthetase 1
  • Synonyms
    NEDMAS, SARS, SERRS, SERS
  • Links
    NCBI Gene ID: 6301
    neXtProt AC: NX_P49591
    UniProt: P49591

  • Chr Location
    1p13.3; chr1:109213893-109238182 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SARS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality before implantation with abnormal morula morphology, increased cell death, and failure of blastocyst formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    162
  • cDNA Data
    197
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068739 Ensembl Gene Model | MGI Sequence Detail 20345 C57BL/6J ±  kb
    transcript ENSMUST00000102625 Ensembl | MGI Sequence Detail 1866 Not Applicable  
    polypeptide ENSMUSP00000099685 Ensembl | MGI Sequence Detail 536 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000014459 serine--tRNA ligase, cytoplasmic
      (term hierarchy)
    • EC
      6.1.1.11
    • InterPro Domains
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
      IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
      IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
      IPR033729 Serine-tRNA ligase catalytic core domain
      IPR002317 Serine-tRNA ligase, type1
      IPR015866 Serine-tRNA synthetase, type1, N-terminal
      IPR042103 Serine-tRNA synthetase, type1, N-terminal domain superfamily
    • GlyGen
      P26638 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 199
      cDNA 197
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14636, MGD-MRK-19717, MGI:2140054, MGI:7482302
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:11496 Miseta A, et al., Mammalian seryl-tRNA synthetase associates with mRNA in vivo and has homology to elongation factor 1 alpha. J Biol Chem. 1991 Oct 15;266(29):19158-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory