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Lmo1 Gene Detail
Summary
  • Symbol
    Lmo1
  • Name
    LIM domain only 1
  • Synonyms
    Rbtn-1, Rbtn1, Ttg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102812
    NCBI Gene: 109594
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:108737776-108774356 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.21 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    947 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102812
 protein coding gene Chr7:108737776-108774414 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032839
 protein coding gene Chr7:112541866-112579681 (-)
A/J MGP_AJ_G0032823
 protein coding gene Chr7:109776281-109813869 (-)
AKR/J MGP_AKRJ_G0032754
 protein coding gene Chr7:112503397-112541090 (-)
BALB/cJ MGP_BALBcJ_G0032827
 protein coding gene Chr7:109472118-109505276 (-)
C3H/HeJ MGP_C3HHeJ_G0032537
 protein coding gene Chr7:112558710-112602646 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033333
 protein coding gene Chr7:117237776-117269342 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030306
 protein coding gene Chr7:111356968-111393321 (-)
CAST/EiJ MGP_CASTEiJ_G0031865
 protein coding gene Chr7:104077584-104111793 (-)
CBA/J MGP_CBAJ_G0032510
 protein coding gene Chr7:121068776-121103446 (-)
DBA/2J MGP_DBA2J_G0032662
 protein coding gene Chr7:107888139-107919791 (-)
FVB/NJ MGP_FVBNJ_G0032615
 protein coding gene Chr7:107733234-107770408 (-)
LP/J MGP_LPJ_G0032756
 protein coding gene Chr7:114097490-114130717 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032647
 protein coding gene Chr7:122739753-122774474 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033354
 protein coding gene Chr7:111532684-111566079 (-)
PWK/PhJ MGP_PWKPhJ_G0031572
 protein coding gene Chr7:100643885-100722927 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031420
 protein coding gene Chr7:98167231-98253409 (-)
WSB/EiJ MGP_WSBEiJ_G0031978
 protein coding gene Chr7:112365177-112400523 (-)



Homology
more
  • Human Ortholog
    LMO1, LIM domain only 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMO1, LIM domain only 1
  • Synonyms
    RBTN1, RHOM1, TTG1
  • Links
    NCBI Gene ID: 4004
    neXtProt AC: NX_P25800
    UniProt: P25800

  • Chr Location
    11p15.4; chr11:8224309-8268787 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show no overt phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1237
  • Tissues
    290
  • cDNA Data
    38
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109594 NCBI Gene Model | MGI Sequence Detail 36581 C57BL/6J ±  kb
    transcript NM_057173 RefSeq | MGI Sequence Detail 1298 ZRU/MplStud  
    polypeptide Q924W9 UniProt | EBI | MGI Sequence Detail 156 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 5
      cDNA 39
      Primer pair 10
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13796, MGD-MRK-13799, MGD-MRK-19720
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 46
      Gene Ontology 8
      Phenotypes 15
    • Earliest
      J:15547 McGuire EA, et al., The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol. 1989 May;9(5):2124-32
    • Latest
      J:350460 Soussi G, et al., TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory