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Klk1 Gene Detail
Summary
  • Symbol
    Klk1
  • Name
    kallikrein 1
  • Synonyms
    0610007D04Rik, Klk6, mGk-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:102850
    NCBI Gene: 16612
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43874784-43879042 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.74 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    14
  • PCR
    4
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102850
 protein coding gene Chr7:43874784-43879046 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032151
 protein coding gene Chr7:44036549-44373083 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0032064
 protein coding gene Chr7:44486267-44500293 (+)
BALB/cJ MGP_BALBcJ_G0032139
 protein coding gene Chr7:43273636-43326579 (+)
C3H/HeJ MGP_C3HHeJ_G0031856
 protein coding gene Chr7:44992784-45248852 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032636
 protein coding gene Chr7:46613583-46619247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029651
 protein coding gene Chr7:45867177-45871639 (+)
CAST/EiJ MGP_CASTEiJ_G0031187
 protein coding gene Chr7:36203533-36205588 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031975
 protein coding gene Chr7:42911408-42915912 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0032054
 protein coding gene Chr7:44776026-45057670 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0032652
 protein coding gene Chr7:43980443-43984701 (+)
PWK/PhJ MGP_PWKPhJ_G0030909
 protein coding gene Chr7:36371439-36373504 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030745
 protein coding gene Chr7:31661862-31663938 (+)
WSB/EiJ MGP_WSBEiJ_G0031301
 protein coding gene Chr7:44180419-44192006 (+)



Homology
more
  • Human Ortholog
    KLK1, kallikrein 1
  • Vertebrate Orthologs
    14
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLK1, kallikrein 1
  • Synonyms
    hK1, Klk6, KLKR
  • Links
    NCBI Gene ID: 3816
    neXtProt AC: NX_P06870
    UniProt: P06870

  • Chr Location
    19q13.33; chr19:50819146-50823787 (-)  GRCh38
  • Human Ortholog
    KLK2, kallikrein related peptidase 2
  • Synonyms
    hGK-1, hK2, KLK2A2
  • Links
    NCBI Gene ID: 3817
    neXtProt AC: NX_P20151
    UniProt: P20151

  • Chr Location
    19q13.33; chr19:50861568-50880567 (+)  GRCh38
  • Human Ortholog
    KLK3, kallikrein related peptidase 3
  • Synonyms
    APS, hK3, KLK2A1, PSA
  • Links
    NCBI Gene ID: 354
    neXtProt AC: NX_P07288
    UniProt: P07288

  • Chr Location
    19q13.33; chr19:50854915-50860764 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human KLK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    11
  • cDNA Data
    7
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063903 Ensembl Gene Model | MGI Sequence Detail 4259 C57BL/6J ±  kb
    transcript ENSMUST00000075162 Ensembl | MGI Sequence Detail 954 Not Applicable  
    polypeptide ENSMUSP00000074659 Ensembl | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
      3.4.21.35
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    • GlyGen
      P15947 1 site
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 82
      cDNA 10
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11548, MGD-MRK-23683, MGI:1915579
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:7072 Mason AJ, et al., Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983 May 26;303(5915):300-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory