Elk4 MGI Mouse Gene Detail - MGI:102853 - ELK4, member of ETS oncogene family

Symbol

Elk4
Name

ELK4, member of ETS oncogene family
Synonyms

2310011G17Rik, A130026I01Rik, Sap1

Feature Type

protein coding gene
IDs

MGI:102853
NCBI Gene: 13714
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:131935129-131954186 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.24 cM, cytoband E3-G
Mapping Data

3 experiments

SNPs within 2kb

503 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102853	protein coding gene	Chr1:131935129-131960350 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016464	protein coding gene	Chr1:135466747-135495048 (+)
A/J	MGP_AJ_G0016447	protein coding gene	Chr1:130449614-130474606 (+)
AKR/J	MGP_AKRJ_G0016412	protein coding gene	Chr1:134279396-134306554 (+)
BALB/cJ	MGP_BALBcJ_G0016407	protein coding gene	Chr1:130769918-130795050 (+)
C3H/HeJ	MGP_C3HHeJ_G0016233	protein coding gene	Chr1:134428297-134454597 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016868	protein coding gene	Chr1:140506180-140532287 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014579	protein coding gene	Chr1:123592781-123618551 (+)
CAST/EiJ	MGP_CASTEiJ_G0015813	protein coding gene	Chr1:133429012-133454883 (+)
CBA/J	MGP_CBAJ_G0016205	protein coding gene	Chr1:145286931-145314140 (+)
DBA/2J	MGP_DBA2J_G0016312	protein coding gene	Chr1:129413291-129439187 (+)
FVB/NJ	MGP_FVBNJ_G0016311	protein coding gene	Chr1:128036260-128061785 (+)
LP/J	MGP_LPJ_G0016383	protein coding gene	Chr1:136776704-136802007 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016336	protein coding gene	Chr1:151079341-151106622 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016904	protein coding gene	Chr1:134041506-134069047 (+)
PWK/PhJ	MGP_PWKPhJ_G0015599	protein coding gene	Chr1:128388809-128415093 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015386	protein coding gene	Chr1:132985578-133011481 (+)
WSB/EiJ	MGP_WSBEiJ_G0015875	protein coding gene	Chr1:134028196-134053665 (+)

Human Ortholog

ELK4, ETS transcription factor ELK4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELK4, ETS transcription factor ELK4
Synonyms

SAP1
Links

HGNC:3326

NCBI Gene ID: 2005

neXtProt AC: NX_P28324

UniProt: P28324
Chr Location

1q32.1; chr1:205597556-205632011 (-) GRCh38

MGI Vertebrate Homology

Elk4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ELK4
Gene Tree

Elk4

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Phenotype Summary

32 phenotypes from 2 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Elk4
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutation of this locus impairs thymocyte positive selection and results in reduced numbers of single-positive thymocytes and peripheral T cells.

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All GO Annotations

19
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

907
Tissues

96
cDNA Data

16
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase elk4

ZFIN elk4

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All Sequences

76
RefSeq

16
UniProt

9
CCDS

CCDS35704.1

Ensembl

ENSMUSG00000026436 (Evidence)
NCBI Gene

13714

			Length	Strain/Species	Flank
genomic	13714	NCBI Gene Model \| MGI Sequence Detail	19058	C57BL/6J	± kb
transcript	NM_001376956	RefSeq \| MGI Sequence Detail	4678	C57BL/6
polypeptide	P41158	UniProt \| EBI \| MGI Sequence Detail	430	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007027 ETS domain-containing protein Elk-4

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR046328 ETS family

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 18

cDNA 17

Other 1

Microarray probesets 8

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MGD-MRK-23686, MGI:1916854, MGI:2138642, MGI:2441777

Summaries

All 63

Developmental Gene Expression 13

Gene Ontology 4

Phenotypes 21
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Elk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8701	Chr1:131935116-131935130 (+)	-6 bp
Tssr203	Chr1:131935133-131935156 (+)	16 bp
Tssr8702	Chr1:131935292-131935329 (+)	182 bp
Tssr8703	Chr1:131935344-131935372 (+)	229 bp
Tssr8704	Chr1:131935378-131935411 (+)	266 bp
Tssr8705	Chr1:131935831-131935892 (+)	733 bp
Tssr8706	Chr1:131936023-131936054 (+)	910 bp
Tssr8707	Chr1:131936062-131936095 (+)	950 bp
Tssr8708	Chr1:131936107-131936135 (+)	992 bp
Tssr207	Chr1:131936285-131936322 (+)	1,175 bp
Tssr8709	Chr1:131936598-131936623 (+)	1,482 bp
Tssr8710	Chr1:131936638-131936648 (+)	1,514 bp
Tssr8711	Chr1:131942260-131942273 (+)	7,138 bp
Tssr8712	Chr1:131945487-131945507 (+)	10,368 bp
Tssr8713	Chr1:131951618-131951623 (+)	16,492 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24