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Dgka Gene Detail
Summary
  • Symbol
    Dgka
  • Name
    diacylglycerol kinase, alpha
  • Synonyms
    Dagk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102952
    NCBI Gene: 13139
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128556003-128580724 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.14 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    548 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102952
 protein coding gene Chr10:128556000-128581002 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017880
 protein coding gene Chr10:132492787-132533569 (-)
A/J MGP_AJ_G0017855
 protein coding gene Chr10:127172518-127195526 (-)
AKR/J MGP_AKRJ_G0017818
 protein coding gene Chr10:130887689-130913213 (-)
BALB/cJ MGP_BALBcJ_G0017819
 protein coding gene Chr10:127537232-127554599 (-)
C3H/HeJ MGP_C3HHeJ_G0017642
 protein coding gene Chr10:131057852-131081766 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018274
 protein coding gene Chr10:136966752-137000555 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015952
 protein coding gene Chr10:121085306-121111046 (-)
CAST/EiJ MGP_CASTEiJ_G0017203
 protein coding gene Chr10:131780435-131805639 (-)
CBA/J MGP_CBAJ_G0017612
 protein coding gene Chr10:142559835-142589032 (-)
DBA/2J MGP_DBA2J_G0017718
 protein coding gene Chr10:126231944-126256086 (-)
FVB/NJ MGP_FVBNJ_G0017713
 protein coding gene Chr10:125155586-125173266 (-)
LP/J MGP_LPJ_G0017792
 protein coding gene Chr10:133082499-133107545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017741
 protein coding gene Chr10:145122281-145149616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018314
 protein coding gene Chr10:130993201-131019251 (-)
PWK/PhJ MGP_PWKPhJ_G0016988
 protein coding gene Chr10:126488908-126520072 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016777
 protein coding gene Chr10:130107404-130130508 (-)
WSB/EiJ MGP_WSBEiJ_G0017262
 protein coding gene Chr10:131215697-131241225 (-)



Homology
more
  • Human Ortholog
    DGKA, diacylglycerol kinase alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKA, diacylglycerol kinase alpha
  • Synonyms
    DAGK, DAGK1, DGK-alpha
  • Links
    NCBI Gene ID: 1606
    neXtProt AC: NX_P23743
    UniProt: P23743

  • Chr Location
    12q13.2; chr12:55927316-55954027 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired induction of T cell anergy. T cells stimulated in anergy producing conditions show increased proliferation and interleukin 2 production. Mice homozygous for a transgenic gene disruption exhibit male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    903
  • Tissues
    112
  • cDNA Data
    77
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025357 Ensembl Gene Model | MGI Sequence Detail 24722 C57BL/6J ±  kb
transcript ENSMUST00000026414 Ensembl | MGI Sequence Detail 2834 Not Applicable  
polypeptide ENSMUSP00000026414 Ensembl | MGI Sequence Detail 730 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 78
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-23787, MGI:2143820
References
more
  • Summaries
    All 73
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 32
  • Earliest
    J:25236 Pilz A, et al., Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene. Genomics. 1995 Apr 10;26(3):599-601
  • Latest
    J:353666 Kudek MR, et al., Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase alpha-Deficient Mice. J Immunol. 2023 May 1;210(9):1281-1291
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory