Txk MGI Mouse Gene Detail - MGI:102960

Symbol

Txk
Name

TXK tyrosine kinase
Synonyms

A130089B16Rik, Btkl, PTK4, Rlk

Feature Type

protein coding gene
IDs

MGI:102960
NCBI Gene: 22165
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:72853321-72910120 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 38.44 cM
Mapping Data

6 experiments

SNPs within 2kb

2071 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102960	protein coding gene	Chr5:72853321-72910337 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029616	protein coding gene	Chr5:72637360-72701306 (-)
A/J	MGP_AJ_G0029584	protein coding gene	Chr5:69931496-69988926 (-)
AKR/J	MGP_AKRJ_G0029532	protein coding gene	Chr5:72169335-72229232 (-)
BALB/cJ	MGP_BALBcJ_G0029592	protein coding gene	Chr5:70626483-70683255 (-)
C3H/HeJ	MGP_C3HHeJ_G0029317	protein coding gene	Chr5:72546384-72609959 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030047	protein coding gene	Chr5:75629756-75690818 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027289	protein coding gene	Chr5:65638367-65695655 (-)
CAST/EiJ	MGP_CASTEiJ_G0028726	protein coding gene	Chr5:71644197-71708734 (-)
CBA/J	MGP_CBAJ_G0029285	protein coding gene	Chr5:78063896-78130755 (-)
DBA/2J	MGP_DBA2J_G0029432	protein coding gene	Chr5:69973877-70035877 (-)
FVB/NJ	MGP_FVBNJ_G0029392	protein coding gene	Chr5:69149718-69206399 (-)
LP/J	MGP_LPJ_G0029516	protein coding gene	Chr5:73093286-73152351 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029418	protein coding gene	Chr5:81422397-81481664 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030081	protein coding gene	Chr5:71743858-71801980 (-)
PWK/PhJ	MGP_PWKPhJ_G0028448	protein coding gene	Chr5:68958813-69017937 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028281	protein coding gene	Chr5:71079351-71136709 (-)
WSB/EiJ	MGP_WSBEiJ_G0028806	protein coding gene	Chr5:72026668-72089705 (-)

Human Ortholog

TXK, TXK tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TXK, TXK tyrosine kinase
Synonyms

BTKL, PSCTK5, PTK4, RLK, TKL
Links

HGNC:12434

NCBI Gene ID: 7294

neXtProt AC: NX_P42681

UniProt: P42681
Chr Location

4p12; chr4:48066393-48134250 (-) GRCh38

MGI Vertebrate Homology

Txk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TXK
Gene Tree

Txk

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

4 involving Txk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available

Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

840
Tissues

29
cDNA Data

37
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

12
UniProt

4
CCDS

CCDS19334.1, CCDS51514.1, CCDS80298.1, CCDS80299.1

Ensembl

ENSMUSG00000054892 (Evidence)
NCBI Gene

22165

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054892	Ensembl Gene Model \| MGI Sequence Detail	56800	C57BL/6J	± kb
transcript	ENSMUST00000169534	Ensembl \| MGI Sequence Detail	2344	Not Applicable
polypeptide	ENSMUSP00000129397	Ensembl \| MGI Sequence Detail	527	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016850 tyrosine-protein kinase TXK

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR035870 Tyrosine-protein kinase TXK, SH2 domain

IPR035579 Tyrosine-protein kinase TXK, SH3 domain

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All nucleic 40

Genomic 1

cDNA 37

Primer pair 2

Microarray probesets 4

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MGD-MRK-23796, MGI:2444219

Summaries

All 82

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 41
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Txk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51328	Chr5:72910131-72910140 (-)	-16 bp
Tssr51327	Chr5:72910106-72910127 (-)	3 bp
Tssr51326	Chr5:72910075-72910105 (-)	30 bp
Tssr51325	Chr5:72893941-72893953 (-)	16,173 bp
Tssr51324	Chr5:72893883-72893918 (-)	16,219 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24