About   Help   FAQ
Srprb Gene Detail
Summary
  • Symbol
    Srprb
  • Name
    signal recognition particle receptor, B subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:102964
    NCBI Gene: 20818
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:103065232-103079264 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 55.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    600 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102964
 protein coding gene Chr9:103065231-103079336 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035194
 protein coding gene Chr9:104797659-104814779 (-)
A/J MGP_AJ_G0035174
 protein coding gene Chr9:101024991-101038959 (-)
AKR/J MGP_AKRJ_G0035106
 protein coding gene Chr9:103523469-103538690 (-)
BALB/cJ MGP_BALBcJ_G0035167
 protein coding gene Chr9:100738347-100752631 (-)
C3H/HeJ MGP_C3HHeJ_G0034877
 protein coding gene Chr9:103916150-103931455 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035687
 protein coding gene Chr9:107706345-107723222 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032586
 protein coding gene Chr9:98607201-98620718 (-)
CAST/EiJ MGP_CASTEiJ_G0034189
 protein coding gene Chr9:103761202-103778560 (-)
CBA/J MGP_CBAJ_G0034846
 protein coding gene Chr9:111471989-111491188 (-)
DBA/2J MGP_DBA2J_G0035007
 protein coding gene Chr9:100515705-100530175 (-)
FVB/NJ MGP_FVBNJ_G0034955
 protein coding gene Chr9:99318289-99331999 (-)
LP/J MGP_LPJ_G0035083
 protein coding gene Chr9:105000795-105015735 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034994
 protein coding gene Chr9:113271418-113287432 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035709
 protein coding gene Chr9:103774050-103790016 (-)
PWK/PhJ MGP_PWKPhJ_G0033896
 protein coding gene Chr9:100773984-100788807 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033731
 protein coding gene Chr9:103822847-103838985 (-)
WSB/EiJ MGP_WSBEiJ_G0034309
 protein coding gene Chr9:103659700-103675360 (-)



Homology
more
  • Human Ortholog
    SRPRB, SRP receptor subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRPRB, SRP receptor subunit beta
  • Synonyms
    APMCF1, SR-beta
  • Links
    NCBI Gene ID: 58477
    neXtProt AC: NX_Q9Y5M8
    UniProt: Q9Y5M8

  • Chr Location
    3q22.1; chr3:133784023-133828574 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    854
  • Tissues
    46
  • cDNA Data
    142
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20818 NCBI Gene Model | MGI Sequence Detail 14033 C57BL/6J ±  kb
    transcript NM_009275 RefSeq | MGI Sequence Detail 2991 C57BL/6  
    polypeptide P47758 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015633 signal recognition particle receptor subunit beta
      (term hierarchy)
    • PDB
      2FH5, 2GO5
    • InterPro Domains
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR019009 Signal recognition particle receptor, beta subunit
      IPR024156 Small GTPase superfamily, ARF type
    • GlyGen
      P47758 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 142

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-23801, MGI:2142932
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:22490 Miller JD, et al., The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. J Cell Biol. 1995 Feb;128(3):273-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory