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Mtnr1a Gene Detail
Summary
  • Symbol
    Mtnr1a
  • Name
    melatonin receptor 1A
  • Synonyms
    Mel1a receptor, MelR
  • Feature Type
    protein coding gene
  • IDs
    MGI:102967
    NCBI Gene: 17773
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:45522174-45541543 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 24.95 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    790 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102967
 protein coding gene Chr8:45522144-45542270 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033571
 protein coding gene Chr8:44089162-44108579 (+)
A/J MGP_AJ_G0033553
 protein coding gene Chr8:42406211-42426226 (+)
AKR/J MGP_AKRJ_G0033478
 protein coding gene Chr8:43650064-43670225 (+)
BALB/cJ MGP_BALBcJ_G0033550
 protein coding gene Chr8:42569476-42591211 (+)
C3H/HeJ MGP_C3HHeJ_G0033259
 protein coding gene Chr8:44152075-44171260 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034066
 protein coding gene Chr8:45765319-45785807 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031015
 protein coding gene Chr8:38696787-38716545 (+)
CAST/EiJ MGP_CASTEiJ_G0032585
 protein coding gene Chr8:43583915-43603881 (+)
CBA/J MGP_CBAJ_G0033238
 protein coding gene Chr8:47615012-47636642 (+)
DBA/2J MGP_DBA2J_G0033391
 protein coding gene Chr8:42220496-42239435 (+)
FVB/NJ MGP_FVBNJ_G0033332
 protein coding gene Chr8:41719506-41738461 (+)
LP/J MGP_LPJ_G0033479
 protein coding gene Chr8:44116889-44136857 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033377
 protein coding gene Chr8:47704581-47723559 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034084
 protein coding gene Chr8:43804368-43823311 (+)
PWK/PhJ MGP_PWKPhJ_G0032293
 protein coding gene Chr8:41743519-41763082 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032129
 protein coding gene Chr8:42970236-42988951 (+)
WSB/EiJ MGP_WSBEiJ_G0032701
 protein coding gene Chr8:44055825-44075978 (+)



Homology
more
  • Human Ortholog
    MTNR1A, melatonin receptor 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTNR1A, melatonin receptor 1A
  • Synonyms
    MEL-1A-R, MT1
  • Links
    NCBI Gene ID: 4543
    neXtProt AC: NX_P48039
    UniProt: P48039

  • Chr Location
    4q35.2; chr4:186526792-186555567 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are essentially normal, with normal circadian functions. In vitro studies report the absence of inhibitory effects of melatonin on suprachiasma neuronal firing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    63
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054764 Ensembl Gene Model | MGI Sequence Detail 19370 C57BL/6J ±  kb
    transcript ENSMUST00000067984 Ensembl | MGI Sequence Detail 1576 Not Applicable  
    polypeptide ENSMUSP00000069872 Ensembl | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 4
      cDNA 6
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23804
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:26189 Slaugenhaupt SA, et al., Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 1995 May 20;27(2):355-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory