Gcsam MGI Mouse Gene Detail - MGI:102969 - germinal center associated, signaling and motility

Symbol

Gcsam
Name

germinal center associated, signaling and motility
Synonyms

Gcet2, M17

Feature Type

protein coding gene
IDs

MGI:102969
NCBI Gene: 14525
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:45430803-45443230 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 29.72 cM, cytoband B5
Mapping Data

3 experiments

SNPs within 2kb

511 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102969	protein coding gene	Chr16:45430743-45443230 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022854	protein coding gene	Chr16:44391484-44404185 (+)
A/J	MGP_AJ_G0022819	protein coding gene	Chr16:42409059-42422381 (+)
AKR/J	MGP_AKRJ_G0022791	protein coding gene	Chr16:43800982-43813533 (+)
BALB/cJ	MGP_BALBcJ_G0022820	protein coding gene	Chr16:42430345-42443319 (+)
C3H/HeJ	MGP_C3HHeJ_G0022584	protein coding gene	Chr16:43965459-43977864 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023267	protein coding gene	Chr16:45412709-45426001 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020781	protein coding gene	Chr16:42764994-42777523 (+)
CAST/EiJ	MGP_CASTEiJ_G0022109	protein coding gene	Chr16:44155545-44168959 (+)
CBA/J	MGP_CBAJ_G0022555	protein coding gene	Chr16:47319917-47332618 (+)
DBA/2J	MGP_DBA2J_G0022687	protein coding gene	Chr16:42147208-42159623 (+)
FVB/NJ	MGP_FVBNJ_G0022663	protein coding gene	Chr16:42059319-42072069 (+)
LP/J	MGP_LPJ_G0022755	protein coding gene	Chr16:44128831-44141295 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022681	protein coding gene	Chr16:46736468-46749950 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023282	protein coding gene	Chr16:43814491-43827854 (+)
PWK/PhJ	MGP_PWKPhJ_G0021849	protein coding gene	Chr16:42514826-42527299 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021680	protein coding gene	Chr16:43753560-43765906 (+)
WSB/EiJ	MGP_WSBEiJ_G0022154	protein coding gene	Chr16:43911045-43923423 (+)

Human Ortholog

GCSAM, germinal center associated signaling and motility

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GCSAM, germinal center associated signaling and motility
Synonyms

GCAT2, GCET2, HGAL
Links

HGNC:20253

NCBI Gene ID: 257144

neXtProt AC: NX_Q8N6F7

UniProt: Q8N6F7
Chr Location

3q13.2; chr3:112120839-112133270 (-) GRCh38

MGI Vertebrate Homology

Gcsam stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GCSAM
Gene Tree

Gcsam

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in a decreased number of and smaller Peyer's patches.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

752
Tissues

45
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

4
UniProt

1
CCDS

CCDS28199.1, CCDS49861.1

Ensembl

ENSMUSG00000022659 (Evidence)
NCBI Gene

14525

			Length	Strain/Species	Flank
genomic	14525	NCBI Gene Model \| MGI Sequence Detail	12428	C57BL/6J	± kb
transcript	NM_001159297	RefSeq \| MGI Sequence Detail	3364	C57BL/6
polypeptide	Q6RFH4	UniProt \| EBI \| MGI Sequence Detail	181	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007889 germinal center-associated signaling and motility protein

(term hierarchy)
InterPro Domains

IPR031364 Germinal centre-associated lymphoma protein

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All nucleic 25

Genomic 6

cDNA 18

Primer pair 1

Microarray probesets 5

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MGD-MRK-23806

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 2
Earliest

J:20385 Christoph T, et al., M17: a novel gene expressed in germinal centers. Int Immunol. 1994 Aug;6(8):1203-11
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Gcsam:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138631	Chr16:45430780-45430801 (+)	-12 bp
Tssr138632	Chr16:45430804-45430813 (+)	6 bp
Tssr138633	Chr16:45430819-45430830 (+)	22 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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