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Il15 Gene Detail
Summary
  • Symbol
    Il15
  • Name
    interleukin 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:103014
    NCBI Gene: 16168
  • Alliance
    gene page
  • Transcription Start Sites
    51 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:83058261-83129851 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 39.33 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1953 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103014
 protein coding gene Chr8:83058253-83129883 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033823
 protein coding gene Chr8:83106433-83191670 (-)
A/J MGP_AJ_G0033806
 protein coding gene Chr8:79846129-79922768 (-)
AKR/J MGP_AKRJ_G0033732
 protein coding gene Chr8:82195466-82276779 (-)
BALB/cJ MGP_BALBcJ_G0033799
 protein coding gene Chr8:79959585-80030290 (-)
C3H/HeJ MGP_C3HHeJ_G0033508
 protein coding gene Chr8:82849595-82922784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034319
 protein coding gene Chr8:86321464-86399052 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031260
 protein coding gene Chr8:73748691-73822576 (-)
CAST/EiJ MGP_CASTEiJ_G0032839
 protein coding gene Chr8:82244025-82318725 (-)
CBA/J MGP_CBAJ_G0033487
 protein coding gene Chr8:89373239-89452710 (-)
DBA/2J MGP_DBA2J_G0033640
 protein coding gene Chr8:79517125-79589621 (-)
FVB/NJ MGP_FVBNJ_G0033585
 protein coding gene Chr8:78428121-78504478 (-)
LP/J MGP_LPJ_G0033730
 protein coding gene Chr8:83229039-83303842 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033628
 protein coding gene Chr8:91916329-91999766 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034336
 protein coding gene Chr8:82211928-82282571 (-)
PWK/PhJ MGP_PWKPhJ_G0032542
 protein coding gene Chr8:78744560-78820469 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032380
 protein coding gene Chr8:80987938-81063382 (-)
WSB/EiJ MGP_WSBEiJ_G0032952
 protein coding gene Chr8:82586503-82665449 (-)



Homology
more
  • Human Ortholog
    IL15, interleukin 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL15, interleukin 15
  • Synonyms
    IL-15
  • Links
    NCBI Gene ID: 3600
    neXtProt AC: NX_P40933
    UniProt: P40933

  • Chr Location
    4q31.21; chr4:141636583-141733987 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IL15 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 7 alleles in 8 genetic backgrounds
    16 phenotypes from multigenic genotypes
    1 images
    277 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene have normal life spans but display a variety of immune system abnormalities and maternal placental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    41
  • cDNA Data
    9
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031712 Ensembl Gene Model | MGI Sequence Detail 71591 C57BL/6J ±  kb
    transcript ENSMUST00000034148 Ensembl | MGI Sequence Detail 1908 Not Applicable  
    polypeptide ENSMUSP00000034148 Ensembl | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 6
      cDNA 9
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23851, MGI:2142577
    References
    more
    • Summaries
      All 451
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 277
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:347748 Bourayou E, et al., Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis. Cell Rep. 2024 Jan 23;43(1):113676
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory