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Ppp1ca Gene Detail
Summary
  • Symbol
    Ppp1ca
  • Name
    protein phosphatase 1 catalytic subunit alpha
  • Synonyms
    dism2, Ppp1c
  • Feature Type
    protein coding gene
  • IDs
    MGI:103016
    NCBI Gene: 19045
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4242173-4245418 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.89 cM, cytoband E3-F2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103016
 protein coding gene Chr19:4242064-4245419 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024655
 protein coding gene Chr19:1034783-1039645 (+)
A/J MGP_AJ_G0024621
 protein coding gene Chr19:993943-997207 (+)
AKR/J MGP_AKRJ_G0024594
 protein coding gene Chr19:1018665-1021924 (+)
BALB/cJ MGP_BALBcJ_G0024621
 protein coding gene Chr19:984690-987955 (+)
C3H/HeJ MGP_C3HHeJ_G0024389
 protein coding gene Chr19:1015049-1019352 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025069
 protein coding gene Chr19:1070990-1074256 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022498
 protein coding gene Chr19:937413-940665 (+)
CAST/EiJ MGP_CASTEiJ_G0023861
 protein coding gene Chr19:1030692-1033970 (+)
CBA/J MGP_CBAJ_G0024360
 protein coding gene Chr19:1133352-1136612 (+)
DBA/2J MGP_DBA2J_G0024488
 protein coding gene Chr19:954682-957943 (+)
FVB/NJ MGP_FVBNJ_G0024455
 protein coding gene Chr19:963881-967142 (+)
LP/J MGP_LPJ_G0024574
 protein coding gene Chr19:1028396-1031658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024485
 protein coding gene Chr19:1076613-1079876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025116
 protein coding gene Chr19:1019385-1022646 (+)
PWK/PhJ MGP_PWKPhJ_G0023607
 protein coding gene Chr19:1007824-1011181 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023412
 protein coding gene Chr19:1001039-1004306 (+)
WSB/EiJ MGP_WSBEiJ_G0023923
 protein coding gene Chr19:1005277-1010223 (+)



Homology
more
  • Human Ortholog
    PPP1CA, protein phosphatase 1 catalytic subunit alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1CA, protein phosphatase 1 catalytic subunit alpha
  • Synonyms
    PP-1A, PP1A, PP1alpha, PPP1A
  • Links
    NCBI Gene ID: 5499
    neXtProt AC: NX_P62136
    UniProt: P62136

  • Chr Location
    11q13.2; chr11:67398181-67421183 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    104
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    50
  • cDNA Data
    21
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 19045 NCBI Gene Model | MGI Sequence Detail 3246 C57BL/6J ±  kb
transcript NM_031868 RefSeq | MGI Sequence Detail 1363 C57BL/6  
polypeptide P62137 UniProt | EBI | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003209 serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    (term hierarchy)
  • PDB
    5ZQV, 5ZT0
  • EC
    3.1.3.16
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR031675 Serine-threonine protein phosphatase, N-terminal
    IPR050341 Serine/threonine-protein phosphatase PP1 catalytic subunit
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
  • GlyGen
    P62137 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 28
    cDNA 22
    Primer pair 3
    Other 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-23853
References
more
  • Summaries
    All 79
    Developmental Gene Expression 10
    Gene Ontology 28
    Phenotypes 7
  • Earliest
    J:22480 Saadat M, et al., Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization. Jpn J Genet. 1994 Dec;69(6):697-700
  • Latest
    J:333724 Park EJ, et al., Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory