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Syn2 Gene Detail
Summary
  • Symbol
    Syn2
  • Name
    synapsin II
  • Synonyms
    2900074L19Rik, Synapsin IIa, Synapsin IIb
  • Feature Type
    protein coding gene
  • IDs
    MGI:103020
    NCBI Gene: 20965
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115111863-115258967 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.20 cM, cytoband F
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3551 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103020
 protein coding gene Chr6:115111863-115259587 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031145
 protein coding gene Chr6:117739969-117894188 (+)
A/J MGP_AJ_G0031114
 protein coding gene Chr6:113223014-113368087 (+)
AKR/J MGP_AKRJ_G0031045
 protein coding gene Chr6:116261872-116423981 (+)
BALB/cJ MGP_BALBcJ_G0031125
 protein coding gene Chr6:113036286-113181967 (+)
C3H/HeJ MGP_C3HHeJ_G0030581
 protein coding gene Chr6:67877425-68036203 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031584
 protein coding gene Chr6:120737413-120898714 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028748
 protein coding gene Chr6:110239384-110384962 (+)
CAST/EiJ MGP_CASTEiJ_G0030232
 protein coding gene Chr6:116616060-116774550 (+)
CBA/J MGP_CBAJ_G0030811
 protein coding gene Chr6:125493617-125656372 (+)
DBA/2J MGP_DBA2J_G0030964
 protein coding gene Chr6:112154472-112301812 (+)
FVB/NJ MGP_FVBNJ_G0030918
 protein coding gene Chr6:111316576-111465793 (+)
LP/J MGP_LPJ_G0031044
 protein coding gene Chr6:117761484-117910696 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030952
 protein coding gene Chr6:129683388-129850706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031611
 protein coding gene Chr6:116277437-116433334 (+)
PWK/PhJ MGP_PWKPhJ_G0029948
 protein coding gene Chr6:111149195-111300302 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029776
 protein coding gene Chr6:114984525-115133196 (+)
WSB/EiJ MGP_WSBEiJ_G0030316
 protein coding gene Chr6:116524355-116681373 (+)



Homology
more
  • Human Ortholog
    SYN2, synapsin II
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYN2, synapsin II
  • Synonyms
    SYNII
  • Links
    NCBI Gene ID: 6854
    neXtProt AC: NX_Q92777
    UniProt: Q92777

  • Chr Location
    3p25.2; chr3:12004388-12192032 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Syn2 mouse models; 1 with human SYN2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in central nervous system abnormalities. One model showed delayed synapse formation and decreased brain weight while another allele showed decreased post-tetanic potentiation and increased synaptic depression and development of convulsive seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    68
  • cDNA Data
    10
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009394 Ensembl Gene Model | MGI Sequence Detail 147105 C57BL/6J ±  kb
    transcript ENSMUST00000009538 Ensembl | MGI Sequence Detail 2708 Not Applicable  
    polypeptide ENSMUSP00000009538 Ensembl | MGI Sequence Detail 586 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 7
      cDNA 11
      Primer pair 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-23857, MGI:1914524, MGI:2141475, MGI:2141484
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 18
      Diseases 3
      Gene Ontology 11
      Phenotypes 68
    • Earliest
      J:3250 Oettinger HF, et al., Chromosome mapping of the murine syndecan gene. Genomics. 1991 Oct;11(2):334-8
    • Latest
      J:359062 Stavsky A, et al., Synapsin E-domain is essential for alpha-synuclein function. Elife. 2024 May 7;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory