Tarbp2 MGI Mouse Gene Detail - MGI:103027 - TARBP2, RISC loading complex RNA binding subunit

Symbol

Tarbp2
Name

TARBP2, RISC loading complex RNA binding subunit
Synonyms

Prbp, TRBP

Feature Type

protein coding gene
IDs

MGI:103027
NCBI Gene: 21357
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:102426627-102432111 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.65 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

117 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103027	protein coding gene	Chr15:102423327-102432112 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022418	protein coding gene	Chr15:104707998-104716640 (+)
A/J	MGP_AJ_G0022380	protein coding gene	Chr15:100582724-100588208 (+)
AKR/J	MGP_AKRJ_G0022355	protein coding gene	Chr15:103627872-103640254 (+)
BALB/cJ	MGP_BALBcJ_G0022384	protein coding gene	Chr15:100638315-100644217 (+)
C3H/HeJ	MGP_C3HHeJ_G0022151	protein coding gene	Chr15:103707005-103713300 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022833	protein coding gene	Chr15:108605932-108613539 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020356	protein coding gene	Chr15:96359642-96365100 (+)
CAST/EiJ	MGP_CASTEiJ_G0021677	protein coding gene	Chr15:104585809-104591287 (+)
CBA/J	MGP_CBAJ_G0022120	protein coding gene	Chr15:112415828-112424584 (+)
DBA/2J	MGP_DBA2J_G0022251	protein coding gene	Chr15:99866487-99872482 (+)
FVB/NJ	MGP_FVBNJ_G0022227	protein coding gene	Chr15:98928426-98933910 (+)
LP/J	MGP_LPJ_G0022320	protein coding gene	Chr15:104857742-104866892 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022249	protein coding gene	Chr15:115969559-115975043 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022845	protein coding gene	Chr15:103674274-103681376 (+)
PWK/PhJ	MGP_PWKPhJ_G0021417	protein coding gene	Chr15:100032262-100037741 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021249	protein coding gene	Chr15:103513247-103518719 (+)
WSB/EiJ	MGP_WSBEiJ_G0021727	protein coding gene	Chr15:104298414-104304539 (+)

Human Ortholog

TARBP2, TARBP2 subunit of RISC loading complex

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TARBP2, TARBP2 subunit of RISC loading complex
Synonyms

LOQS, TRBP, TRBP1, TRBP2
Links

HGNC:11569

NCBI Gene ID: 6895

neXtProt AC: NX_Q15633

UniProt: Q15633
Chr Location

12q13.13; chr12:53500921-53506431 (+) GRCh38

MGI Vertebrate Homology

Tarbp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TARBP2
Gene Tree

Tarbp2

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References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Gene trapped

17
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Tarbp2
Incidental Mutations

CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene results in lethality at weaning, decreased body weight, and male infertility associated with oligozoospermia and failure of spermiation.

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All GO Annotations

62
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

27
cDNA Data

72
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tarbp2

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All Sequences

139
RefSeq

67
UniProt

10
CCDS

CCDS27886.1, CCDS57013.1

Ensembl

ENSMUSG00000023051 (Evidence)
NCBI Gene

21357

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023051	Ensembl Gene Model \| MGI Sequence Detail	5485	C57BL/6J	± kb
transcript	ENSMUST00000249596	Ensembl \| MGI Sequence Detail	1489	Not Applicable
polypeptide	ENSMUSP00000159805	Ensembl \| MGI Sequence Detail	374	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000016056 RISC-loading complex subunit TARBP2

(term hierarchy)
PDB

7ZPJ, 7ZPK
InterPro Domains

IPR014720 Double-stranded RNA-binding domain

IPR051247 RISC Loading Complex Component

IPR028605 RISC-loading complex subunit TRBP2

IPR044469 TRBP2 , first double-stranded RNA binding domain

IPR044470 TRBP2 , second double-stranded RNA binding domain

IPR044471 TRBP2 , third double-stranded RNA binding domain

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All nucleic 79

Genomic 1

cDNA 74

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-23864, MGD-MRK-37240, MGI:108201

Summaries

All 68

Developmental Gene Expression 5

Diseases 1

Gene Ontology 13

Phenotypes 31
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:290185 Vishlaghi N, et al., Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development. Front Cell Dev Biol. 2020;8:338

TSS for Tarbp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133453	Chr15:102426742-102426766 (+)	127 bp
Tssr133454	Chr15:102426840-102426931 (+)	259 bp
Tssr133455	Chr15:102427149-102427213 (+)	554 bp
Tssr133456	Chr15:102429174-102429182 (+)	2,551 bp
Tssr133457	Chr15:102429233-102429240 (+)	2,610 bp
Tssr133458	Chr15:102429253-102429273 (+)	2,636 bp
Tssr133459	Chr15:102429281-102429300 (+)	2,664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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