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Scg3 Gene Detail
Summary
  • Symbol
    Scg3
  • Name
    secretogranin III
  • Synonyms
    1B1075, Chgd, SgIII
  • Feature Type
    protein coding gene
  • IDs
    MGI:103032
    NCBI Gene: 20255
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75550471-75591338 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1330 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103032
 protein coding gene Chr9:75550471-75591733 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035044
 protein coding gene Chr9:75971124-76016477 (-)
A/J MGP_AJ_G0035025
 protein coding gene Chr9:73316289-73361491 (-)
AKR/J MGP_AKRJ_G0034954
 protein coding gene Chr9:75065957-75107663 (-)
BALB/cJ MGP_BALBcJ_G0035017
 protein coding gene Chr9:72982995-73028130 (-)
C3H/HeJ MGP_C3HHeJ_G0034726
 protein coding gene Chr9:75534263-75595113 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035535
 protein coding gene Chr9:77983442-78027612 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032446
 protein coding gene Chr9:72669791-72710273 (-)
CAST/EiJ MGP_CASTEiJ_G0034048
 protein coding gene Chr9:75884358-75929721 (-)
CBA/J MGP_CBAJ_G0034698
 protein coding gene Chr9:80660966-80715332 (-)
DBA/2J MGP_DBA2J_G0034858
 protein coding gene Chr9:72979921-73029050 (-)
FVB/NJ MGP_FVBNJ_G0034800
 protein coding gene Chr9:72284073-72328370 (-)
LP/J MGP_LPJ_G0034939
 protein coding gene Chr9:76218475-76261853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034841
 protein coding gene Chr9:81736664-81781440 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035558
 protein coding gene Chr9:75231841-75277202 (-)
PWK/PhJ MGP_PWKPhJ_G0033752
 protein coding gene Chr9:73274609-73316176 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033585
 protein coding gene Chr9:75465091-75505650 (-)
WSB/EiJ MGP_WSBEiJ_G0034160
 protein coding gene Chr9:75143716-75190387 (-)



Homology
more
  • Human Ortholog
    SCG3, secretogranin III
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCG3, secretogranin III
  • Synonyms
    SGIII
  • Links
    NCBI Gene ID: 29106
    neXtProt AC: NX_Q8WXD2
    UniProt: Q8WXD2

  • Chr Location
    15q21.2; chr15:51681492-51721026 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout causes dysregulation of the secretion of active peptide hormones from endocrine cells, exacerbating the adverse effects of inadequate diet (obesity, diabetes) and stress conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1001
  • Tissues
    109
  • cDNA Data
    52
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032181 Ensembl Gene Model | MGI Sequence Detail 40868 C57BL/6J ±  kb
    transcript ENSMUST00000034699 Ensembl | MGI Sequence Detail 2384 Not Applicable  
    polypeptide ENSMUSP00000034699 Ensembl | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 52
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18612, MGD-MRK-23869, MGI:2143028
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 15
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:154091 Gogstad GO, et al., Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. Biochim Biophys Acta. 1981 Sep 29;670(2):150-62
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory