Stat5b MGI Mouse Gene Detail - MGI:103035 - signal transducer and activator of transcription 5B

Symbol

Stat5b
Name

signal transducer and activator of transcription 5B

Feature Type

protein coding gene
IDs

MGI:103035
NCBI Gene: 20851
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr11:100671557-100741407 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.63 cM
Mapping Data

7 experiments

SNPs within 2kb

1683 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103035	protein coding gene	Chr11:100671557-100741550 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019171	protein coding gene	Chr11:103554033-103629023 (-)
A/J	MGP_AJ_G0019139	protein coding gene	Chr11:99233313-99302018 (-)
AKR/J	MGP_AKRJ_G0019108	protein coding gene	Chr11:102318613-102391737 (-)
BALB/cJ	MGP_BALBcJ_G0019113	protein coding gene	Chr11:99719529-99788794 (-)
C3H/HeJ	MGP_C3HHeJ_G0018922	protein coding gene	Chr11:102477938-102551693 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019562	protein coding gene	Chr11:106762175-106836431 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017188	protein coding gene	Chr11:96651917-96723733 (-)
CAST/EiJ	MGP_CASTEiJ_G0018476	protein coding gene	Chr11:103465450-103538567 (-)
CBA/J	MGP_CBAJ_G0018891	protein coding gene	Chr11:111226357-111300913 (-)
DBA/2J	MGP_DBA2J_G0019003	protein coding gene	Chr11:98769104-98840300 (-)
FVB/NJ	MGP_FVBNJ_G0018993	protein coding gene	Chr11:98308461-98380475 (-)
LP/J	MGP_LPJ_G0019072	protein coding gene	Chr11:104113339-104182940 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019024	protein coding gene	Chr11:110802423-110874596 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019600	protein coding gene	Chr11:102629687-102704718 (-)
PWK/PhJ	MGP_PWKPhJ_G0018239	protein coding gene	Chr11:99811129-99884940 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018031	protein coding gene	Chr11:102375878-102446338 (-)
WSB/EiJ	MGP_WSBEiJ_G0018525	protein coding gene	Chr11:102623214-102698572 (-)

Human Ortholog

STAT5B, signal transducer and activator of transcription 5B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STAT5B, signal transducer and activator of transcription 5B
Synonyms

GHISID2, STAT5
Links

HGNC:11367

NCBI Gene ID: 6777

neXtProt AC: NX_P51692

UniProt: P51692
Chr Location

17q21.2; chr17:42199176-42288633 (-) GRCh38

MGI Vertebrate Homology

Stat5b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STAT5B
Gene Tree

Stat5b

Diseases

4 with human STAT5B associations

				Human Disease	Mouse Models
				colon adenocarcinoma IDs colon adenocarcinoma DOID:234 MESH:D003110 NCI:C4349 UMLS_CUI:C0338106
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315
				growth hormone insensitivity syndrome with immune dysregulation 1 IDs growth hormone insensitivity syndrome with immune dysregulation 1 DOID:0080836 OMIM:245590 ORDO:220465
				growth hormone insensitivity syndrome with immune dysregulation 2 IDs growth hormone insensitivity syndrome with immune dysregulation 2 DOID:0080837 OMIM:618985

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

79 phenotypes from 4 alleles in 15 genetic backgrounds
80 phenotypes from multigenic genotypes
215 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

1
Gene trapped

2
Targeted

14
Transgenic

1
Genomic Mutations

4 involving Stat5b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this are reduced in size and mammary glands secrete reduced levels of some milk proteins during lactation.

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All GO Annotations

123
GO References

26

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

117
cDNA Data

90
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN stat5a, stat5b

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All Sequences

52
RefSeq

6
UniProt

2
CCDS

CCDS25438.1

Ensembl

ENSMUSG00000020919 (Evidence)
NCBI Gene

20851

			Length	Strain/Species	Flank
genomic	20851	NCBI Gene Model \| MGI Sequence Detail	69851	C57BL/6J	± kb
transcript	NM_001362682	RefSeq \| MGI Sequence Detail	7252	ZRU/MplStud
polypeptide	P42232	UniProt \| EBI \| MGI Sequence Detail	786	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002092 signal transducer and activator of transcription 5b

(term hierarchy)
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR048988 Signal transducer and activator of transcription, linker domain

IPR046994 STAT5a/5b, coiled-coil domain

IPR035858 STAT5a/5b, DNA-binding domain

IPR035886 STAT5b, SH2 domain

IPR013800 STAT transcription factor, all-alpha domain

IPR015988 STAT transcription factor, coiled coil

IPR013801 STAT transcription factor, DNA-binding

IPR012345 STAT transcription factor, DNA-binding, N-terminal

IPR036535 STAT transcription factor, N-terminal domain superfamily

IPR013799 STAT transcription factor, protein interaction

IPR001217 Transcription factor STAT
GlyGen

P42232 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 102

Genomic 6

cDNA 91

Primer pair 5

Microarray probesets 5

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MGD-MRK-23873

Summaries

All 351

Developmental Gene Expression 22

Gene Ontology 26

Phenotypes 215
Earliest

J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
Latest

J:353834 Lin JX, et al., Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation. Nat Commun. 2024 Aug 27;15(1):7372

TSS for Stat5b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110882	Chr11:100741565-100741589 (-)	-170 bp
Tssr110881	Chr11:100741313-100741422 (-)	39 bp
Tssr110880	Chr11:100739230-100739239 (-)	2,172 bp
Tssr110879	Chr11:100738961-100739007 (-)	2,423 bp
Tssr110878	Chr11:100736882-100736890 (-)	4,521 bp
Tssr110877	Chr11:100736833-100736844 (-)	4,568 bp
Tssr110876	Chr11:100736723-100736737 (-)	4,677 bp
Tssr110875	Chr11:100713351-100713402 (-)	28,030 bp
Tssr110874	Chr11:100713334-100713343 (-)	28,068 bp
Tssr110873	Chr11:100713306-100713317 (-)	28,095 bp
Tssr110872	Chr11:100711848-100711852 (-)	29,557 bp
Tssr110871	Chr11:100694798-100694812 (-)	46,602 bp
Tssr110870	Chr11:100694675-100694687 (-)	46,726 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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