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Stat2 Gene Detail
Summary
  • Symbol
    Stat2
  • Name
    signal transducer and activator of transcription 2
  • Synonyms
    1600010G07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103039
    NCBI Gene: 20847
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128106428-128128718 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.50 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    557 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103039
 protein coding gene Chr10:128106367-128128722 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017856
 protein coding gene Chr10:131985922-132011423 (+)
A/J MGP_AJ_G0017831
 protein coding gene Chr10:126692450-126714878 (+)
AKR/J MGP_AKRJ_G0017794
 protein coding gene Chr10:130417016-130441564 (+)
BALB/cJ MGP_BALBcJ_G0017795
 protein coding gene Chr10:127075668-127099320 (+)
C3H/HeJ MGP_C3HHeJ_G0017618
 protein coding gene Chr10:130566075-130602545 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018250
 protein coding gene Chr10:136461565-136490450 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015928
 protein coding gene Chr10:120628625-120650531 (+)
CAST/EiJ MGP_CASTEiJ_G0017179
 protein coding gene Chr10:131285263-131307088 (+)
CBA/J MGP_CBAJ_G0017588
 protein coding gene Chr10:141997780-142031339 (+)
DBA/2J MGP_DBA2J_G0017694
 protein coding gene Chr10:125755647-125778200 (+)
FVB/NJ MGP_FVBNJ_G0017689
 protein coding gene Chr10:124684278-124707068 (+)
LP/J MGP_LPJ_G0017768
 protein coding gene Chr10:132583288-132610861 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017717
 protein coding gene Chr10:144598690-144622528 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018290
 protein coding gene Chr10:130509672-130534021 (+)
PWK/PhJ MGP_PWKPhJ_G0016964
 protein coding gene Chr10:126013602-126038003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016753
 protein coding gene Chr10:129599908-129627090 (+)
WSB/EiJ MGP_WSBEiJ_G0017238
 protein coding gene Chr10:130728465-130752866 (+)



Homology
more
  • Human Ortholog
    STAT2, signal transducer and activator of transcription 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAT2, signal transducer and activator of transcription 2
  • Synonyms
    IMD44, ISGF-3, P113, PTORCH3, STAT113
  • Links
    NCBI Gene ID: 6773
    neXtProt AC: NX_P52630
    UniProt: P52630

  • Chr Location
    12q13.3; chr12:56341597-56360203 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human STAT2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Immune response is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    56
  • cDNA Data
    15
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040033 Ensembl Gene Model | MGI Sequence Detail 22291 C57BL/6J ±  kb
transcript ENSMUST00000085708 Ensembl | MGI Sequence Detail 4394 Not Applicable  
polypeptide ENSMUSP00000082855 Ensembl | MGI Sequence Detail 922 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000002088 signal transducer and activator of transcription 2
    (term hierarchy)
  • PDB
    5OEN
  • InterPro Domains
    IPR008967 p53-like transcription factor, DNA-binding domain superfamily
    IPR000980 SH2 domain
    IPR036860 SH2 domain superfamily
    IPR022756 Signal transducer and activation of transcription 2, C-terminal
    IPR048988 Signal transducer and activator of transcription, linker domain
    IPR035854 STAT2, SH2 domain
    IPR013800 STAT transcription factor, all-alpha domain
    IPR015988 STAT transcription factor, coiled coil
    IPR013801 STAT transcription factor, DNA-binding
    IPR012345 STAT transcription factor, DNA-binding, N-terminal
    IPR036535 STAT transcription factor, N-terminal domain superfamily
    IPR013799 STAT transcription factor, protein interaction
    IPR001217 Transcription factor STAT
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-23901, MGI:1919271, MGI:2143845
References
more
  • Summaries
    All 128
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 9
    Phenotypes 64
  • Earliest
    J:25641 Takeuchi T, et al., Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation. Genes Dev. 1995 May 15;9(10):1211-22
  • Latest
    J:349464 Fortelny N, et al., JAK-STAT signaling maintains homeostasis in T cells and macrophages. Nat Immunol. 2024 May;25(5):847-859
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory