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Ecm1 Gene Detail
Summary
  • Symbol
    Ecm1
  • Name
    extracellular matrix protein 1
  • Synonyms
    p85
  • Feature Type
    protein coding gene
  • IDs
    MGI:103060
    NCBI Gene: 13601
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95641459-95646880 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.91 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103060
 protein coding gene Chr3:95641459-95646881 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027592
 protein coding gene Chr3:96503358-96508780 (-)
A/J MGP_AJ_G0027551
 protein coding gene Chr3:93487220-93492640 (-)
AKR/J MGP_AKRJ_G0027518
 protein coding gene Chr3:95665620-95671042 (-)
BALB/cJ MGP_BALBcJ_G0027563
 protein coding gene Chr3:93264637-93270071 (-)
C3H/HeJ MGP_C3HHeJ_G0027296
 protein coding gene Chr3:95960445-95965867 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028011
 protein coding gene Chr3:100054608-100060371 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025351
 protein coding gene Chr3:89815024-89820562 (-)
CAST/EiJ MGP_CASTEiJ_G0026746
 protein coding gene Chr3:95230450-95235971 (-)
CBA/J MGP_CBAJ_G0027273
 protein coding gene Chr3:103716684-103722106 (-)
DBA/2J MGP_DBA2J_G0027412
 protein coding gene Chr3:92775449-92780871 (-)
FVB/NJ MGP_FVBNJ_G0027383
 protein coding gene Chr3:90849983-90855405 (-)
LP/J MGP_LPJ_G0027521
 protein coding gene Chr3:97814674-97820096 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027410
 protein coding gene Chr3:109834279-109839723 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028065
 protein coding gene Chr3:95311733-95317153 (-)
PWK/PhJ MGP_PWKPhJ_G0026474
 protein coding gene Chr3:92668609-92674132 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026295
 protein coding gene Chr3:93596050-93601517 (-)
WSB/EiJ MGP_WSBEiJ_G0026828
 protein coding gene Chr3:95697808-95703244 (-)



Homology
more
  • Human Ortholog
    ECM1, extracellular matrix protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECM1, extracellular matrix protein 1
  • Synonyms
    URBWD
  • Links
    NCBI Gene ID: 1893
    neXtProt AC: NX_Q16610
    UniProt: Q16610

  • Chr Location
    1q21.2; chr1:150508062-150513789 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ECM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit auto-inflammatory disease and do not survive beyond 6 to 8 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    36
  • cDNA Data
    115
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13601 NCBI Gene Model | MGI Sequence Detail 5422 C57BL/6J ±  kb
    transcript NM_001409917 RefSeq | MGI Sequence Detail 1954 ZRU/MplStud  
    polypeptide Q61508 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      cDNA 115
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23922, MGI:2139781
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 12
      Phenotypes 20
    • Earliest
      J:26941 Capeless CG, et al., Hydrolysis of sucrose octa-acetate: qualitative differences in taster and demistaster avoidance phenotypes. Chem Senses. 1994 Dec;19(6):595-607
    • Latest
      J:349886 Yu Y, et al., Remodeling of tumor microenvironment by extracellular matrix protein 1a differentially regulates ovarian cancer metastasis. Cancer Lett. 2024 Aug 1;596:217022
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory