Pura MGI Mouse Gene Detail - MGI:103079 - purine rich element binding protein A

Symbol

Pura
Name

purine rich element binding protein A
Synonyms

CAGER-1, Pur alpha, Pur-alpha, ssCRE-BP

Feature Type

protein coding gene
IDs

MGI:103079
NCBI Gene: 19290
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr18:36414150-36425588 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM, cytoband B3
Mapping Data

1 experiment

SNPs within 2kb

128 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103079	protein coding gene	Chr18:36413614-36434575 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024275	protein coding gene	Chr18:34668094-34688508 (+)
A/J	MGP_AJ_G0024241	protein coding gene	Chr18:33455527-33475951 (+)
AKR/J	MGP_AKRJ_G0024209	protein coding gene	Chr18:34381049-34401470 (+)
BALB/cJ	MGP_BALBcJ_G0024241	protein coding gene	Chr18:33501834-33522256 (+)
C3H/HeJ	MGP_C3HHeJ_G0024008	protein coding gene	Chr18:34458333-34478758 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024682	protein coding gene	Chr18:35884701-35905272 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022122	protein coding gene	Chr18:33546762-33567232 (+)
CAST/EiJ	MGP_CASTEiJ_G0023483	protein coding gene	Chr18:34447649-34459716 (+)
CBA/J	MGP_CBAJ_G0023976	protein coding gene	Chr18:36960907-36981331 (+)
DBA/2J	MGP_DBA2J_G0024108	protein coding gene	Chr18:33079374-33099798 (+)
FVB/NJ	MGP_FVBNJ_G0024075	protein coding gene	Chr18:32776931-32797352 (+)
LP/J	MGP_LPJ_G0024190	protein coding gene	Chr18:34701867-34722288 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024103	protein coding gene	Chr18:38163711-38188358 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024731	protein coding gene	Chr18:34250458-34270880 (+)
PWK/PhJ	MGP_PWKPhJ_G0023227	protein coding gene	Chr18:33324098-33344866 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023034	protein coding gene	Chr18:34509942-34530440 (+)
WSB/EiJ	MGP_WSBEiJ_G0023546	protein coding gene	Chr18:34178886-34199336 (+)

Human Ortholog

PURA, purine rich element binding protein A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PURA, purine rich element binding protein A
Synonyms

MRD31, NEDRIHF, PUR1, PUR-ALPHA, PURALPHA
Links

HGNC:9701

NCBI Gene ID: 5813

neXtProt AC: NX_Q00577

UniProt: Q00577
Chr Location

5q31.3; chr5:140107777-140125619 (+) GRCh38

MGI Vertebrate Homology

Pura stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PURA
Gene Tree

Pura

Diseases

1 with human PURA associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder 31 IDs autosomal dominant intellectual developmental disorder 31 DOID:0070061 OMIM:616158

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

42 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

3
Gene trapped

25
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are overtly normal within the first few weeks of life but later manifest severe neurological defects and die shortly after weaning. Neuroanatomical abnormalities are also observed.

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All GO Annotations

48
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

824
Tissues

112
cDNA Data

9
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pura

ZFIN puraa

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All Sequences

39
RefSeq

6
UniProt

2
CCDS

CCDS29151.1

Ensembl

ENSMUSG00000043991 (Evidence)
NCBI Gene

19290

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043991	Ensembl Gene Model \| MGI Sequence Detail	11439	C57BL/6J	± kb
transcript	ENSMUST00000051301	Ensembl \| MGI Sequence Detail	5957	Not Applicable
polypeptide	ENSMUSP00000059404	Ensembl \| MGI Sequence Detail	321	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013494 transcriptional activator protein Pur-alpha

(term hierarchy)
InterPro Domains

IPR006628 Purine-rich element binding protein family
GlyGen

P42669 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-23943

Summaries

All 58

Developmental Gene Expression 7

Gene Ontology 16

Phenotypes 12
Earliest

J:21627 Ma ZW, et al., Conservation in human and mouse Pur alpha of a motif common to several proteins involved in initiation of DNA replication. Gene. 1994 Nov 18;149(2):311-4
Latest

J:342156 Chuang HC, et al., DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha. J Clin Invest. 2023 Nov 1;133(21)

TSS for Pura:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150596	Chr18:36413604-36413620 (+)	-538 bp
Tssr150597	Chr18:36414122-36414204 (+)	13 bp
Tssr150598	Chr18:36414401-36414439 (+)	270 bp
Tssr150599	Chr18:36414442-36414455 (+)	299 bp
Tssr150600	Chr18:36414499-36414512 (+)	356 bp
Tssr150601	Chr18:36414518-36414557 (+)	388 bp
Tssr150602	Chr18:36414564-36414571 (+)	418 bp
Tssr150603	Chr18:36419415-36419472 (+)	5,294 bp
Tssr150604	Chr18:36420128-36420214 (+)	6,021 bp
Tssr150605	Chr18:36420328-36420339 (+)	6,184 bp
Tssr150606	Chr18:36420951-36420963 (+)	6,807 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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