F10 MGI Mouse Gene Detail - MGI:103107

Symbol

F10
Name

coagulation factor X
Synonyms

AI194738, Cf10, fX

Feature Type

protein coding gene
IDs

MGI:103107
NCBI Gene: 14058
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr8:13087308-13106676 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 5.73 cM
Mapping Data

4 experiments

SNPs within 2kb

748 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103107	protein coding gene	Chr8:13087308-13106676 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033369	protein coding gene	Chr8:10349865-10369343 (+)
A/J	MGP_AJ_G0033349	protein coding gene	Chr8:9982761-10002111 (+)
AKR/J	MGP_AKRJ_G0033280	protein coding gene	Chr8:10248213-10266790 (+)
BALB/cJ	MGP_BALBcJ_G0033350	protein coding gene	Chr8:10123157-10141417 (+)
C3H/HeJ	MGP_C3HHeJ_G0033063	protein coding gene	Chr8:10459942-10478511 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033862	protein coding gene	Chr8:10716801-10736148 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030831	protein coding gene	Chr8:9490030-9511556 (+)
CAST/EiJ	MGP_CASTEiJ_G0032385	protein coding gene	Chr8:10221419-10241058 (+)
CBA/J	MGP_CBAJ_G0033036	protein coding gene	Chr8:11167698-11188921 (+)
DBA/2J	MGP_DBA2J_G0033189	protein coding gene	Chr8:9941589-9960156 (+)
FVB/NJ	MGP_FVBNJ_G0033138	protein coding gene	Chr8:9946395-9965110 (+)
LP/J	MGP_LPJ_G0033283	protein coding gene	Chr8:10272963-10292776 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033172	protein coding gene	Chr8:11424375-11443720 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033879	protein coding gene	Chr8:10312247-10330797 (+)
PWK/PhJ	MGP_PWKPhJ_G0032098	protein coding gene	Chr8:9986371-10006337 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031940	protein coding gene	Chr8:10200756-10219714 (+)
WSB/EiJ	MGP_WSBEiJ_G0032501	protein coding gene	Chr8:10346884-10370210 (+)

Human Ortholog

F10, coagulation factor X

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

F10, coagulation factor X
Synonyms

FX, FXA
Links

HGNC:3528

NCBI Gene ID: 2159

neXtProt AC: NX_P00742

UniProt: P00742
Chr Location

13q34; chr13:113122799-113149529 (+) GRCh38

MGI Vertebrate Homology

F10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: F10
Protein SuperFamily

Factor_X
Gene Tree

F10

Diseases

2 with human F10 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				factor X deficiency IDs factor X deficiency DOID:2222 MESH:D005171 NCI:C131632 OMIM:227600 ORDO:328 UMLS_CUI:C0015519

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

15 phenotypes from 4 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Most homozygous mice die from fatal bleeding events at embryonic and neonatal stages, with the remaining homozygous mice dying before weaning stages.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

739
Tissues

25
cDNA Data

43
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase f10

ZFIN f10

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All Sequences

56
RefSeq

4
UniProt

9
CCDS

CCDS40226.1, CCDS57606.1

Ensembl

ENSMUSG00000031444 (Evidence)
NCBI Gene

14058

			Length	Strain/Species	Flank
genomic	14058	NCBI Gene Model \| MGI Sequence Detail	19369	C57BL/6J	± kb
transcript	NM_001242368	RefSeq \| MGI Sequence Detail	2693	C57BL/6
polypeptide	O88947	UniProt \| EBI \| MGI Sequence Detail	481	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007294 coagulation factor X

(term hierarchy)
EC

3.4.21.6
InterPro Domains

IPR017857 Coagulation factor-like, Gla domain superfamily

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain

IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily

IPR001314 Peptidase S1A, chymotrypsin family

IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z

IPR050442 Peptidase S1 family, coagulation factors

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site
GlyGen

O88947 2 sites

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All nucleic 51

Genomic 3

cDNA 45

Primer pair 3

Microarray probesets 7

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MGD-MRK-23971, MGI:2142475

Summaries

All 65

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 15
Earliest

J:24375 Koizumi T, et al., Homologs of genes and anonymous loci on human chromosome 13 map to mouse chromosomes 8 and 14. Mamm Genome. 1995 Apr;6(4):263-8
Latest

J:358512 Verhenne S, et al., Fitusiran reduces bleeding in factor X-deficient mice. Blood. 2024 Jul 11;144(2):227-236

TSS for F10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76325	Chr8:13087292-13087303 (+)	-10 bp
Tssr76326	Chr8:13087339-13087352 (+)	38 bp
Tssr76327	Chr8:13087357-13087362 (+)	52 bp
Tssr76328	Chr8:13087372-13087390 (+)	73 bp
Tssr76329	Chr8:13087802-13087838 (+)	512 bp
Tssr76330	Chr8:13087976-13087985 (+)	673 bp
Tssr76331	Chr8:13089303-13089304 (+)	1,996 bp
Tssr76332	Chr8:13089326-13089335 (+)	2,023 bp
Tssr76333	Chr8:13089358-13089359 (+)	2,051 bp
Tssr76334	Chr8:13089369-13089397 (+)	2,075 bp
Tssr76335	Chr8:13089537-13089549 (+)	2,235 bp
Tssr76336	Chr8:13092757-13092769 (+)	5,455 bp
Tssr76337	Chr8:13092777-13092790 (+)	5,476 bp
Tssr76338	Chr8:13102285-13102289 (+)	14,979 bp
Tssr76339	Chr8:13105674-13105681 (+)	18,370 bp
Tssr76340	Chr8:13105832-13105843 (+)	18,530 bp
Tssr2495	Chr8:13105848-13105853 (+)	18,543 bp
Tssr76341	Chr8:13105954-13105966 (+)	18,652 bp
Tssr76342	Chr8:13105977-13105988 (+)	18,675 bp
Tssr76343	Chr8:13106027-13106036 (+)	18,724 bp
Tssr76344	Chr8:13106148-13106156 (+)	18,844 bp
Tssr76345	Chr8:13106157-13106175 (+)	18,858 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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