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Gabrg1 Gene Detail
Summary
  • Symbol
    Gabrg1
  • Name
    gamma-aminobutyric acid type A receptor subunit gamma 1
  • Synonyms
    GabaA
  • Feature Type
    protein coding gene
  • IDs
    MGI:103156
    NCBI Gene: 14405
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:70908390-70999960 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 37.43 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2036 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103156
 protein coding gene Chr5:70906512-70999960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029605
 protein coding gene Chr5:70620851-70704676 (-)
A/J MGP_AJ_G0029573
 protein coding gene Chr5:67984613-68071489 (-)
AKR/J MGP_AKRJ_G0029521
 protein coding gene Chr5:70164823-70253152 (-)
BALB/cJ MGP_BALBcJ_G0029582
 protein coding gene Chr5:68654097-68739230 (-)
C3H/HeJ MGP_C3HHeJ_G0029305
 protein coding gene Chr5:70508702-70595684 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030036
 protein coding gene Chr5:73550687-73663526 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027276
 protein coding gene Chr5:63787180-63863506 (-)
CAST/EiJ MGP_CASTEiJ_G0028713
 protein coding gene Chr5:69646921-69741665 (-)
CBA/J MGP_CBAJ_G0029274
 protein coding gene Chr5:75905789-76009423 (-)
DBA/2J MGP_DBA2J_G0029420
 protein coding gene Chr5:68031328-68120002 (-)
FVB/NJ MGP_FVBNJ_G0029380
 protein coding gene Chr5:67212691-67299646 (-)
LP/J MGP_LPJ_G0029505
 protein coding gene Chr5:71080942-71171408 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029408
 protein coding gene Chr5:79113323-79229382 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030069
 protein coding gene Chr5:69738941-69828666 (-)
PWK/PhJ MGP_PWKPhJ_G0028437
 protein coding gene Chr5:67015351-67100460 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028271
 protein coding gene Chr5:69111248-69200035 (-)
WSB/EiJ MGP_WSBEiJ_G0028793
 protein coding gene Chr5:69988216-70079048 (-)



Homology
more
  • Human Ortholog
    GABRG1, gamma-aminobutyric acid type A receptor subunit gamma1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRG1, gamma-aminobutyric acid type A receptor subunit gamma1
  • Links
    NCBI Gene ID: 2565
    neXtProt AC: NX_Q8N1C3
    UniProt: Q8N1C3

  • Chr Location
    4p12; chr4:46035769-46124054 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gabrg1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    40
  • cDNA Data
    22
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001260 Ensembl Gene Model | MGI Sequence Detail 91571 C57BL/6J ±  kb
transcript ENSMUST00000031119 Ensembl | MGI Sequence Detail 4771 Not Applicable  
polypeptide ENSMUSP00000031119 Ensembl | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000007777 gamma-aminobutyric acid receptor subunit gamma-1
    (term hierarchy)
  • InterPro Domains
    IPR005438 Gamma-aminobutyric-acid A receptor, gamma 1 subunit
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR005437 Gamma-aminobutyric acid receptor subunit gamma-1/4
    IPR038050 Neuronal acetylcholine receptor
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
  • GlyGen
    Q9R0Y8 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 38
    Genomic 10
    cDNA 25
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-24022
References
more
  • Summaries
    All 79
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:355330 Neumann E, et al., gamma1 GABA(A) Receptors in Spinal Nociceptive Circuits. J Neurosci. 2024 Oct 9;44(41)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory