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Gfi1 Gene Detail
Summary
  • Symbol
    Gfi1
  • Name
    growth factor independent 1 transcription repressor
  • Synonyms
    Gfi-1, Pal-1, Pal1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103170
    NCBI Gene: 14581
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Regulated by
    Rr258, Rr259, Rr260 ... (5 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr5:107864521-107873671 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 52.23 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103170
 protein coding gene Chr5:107864521-107873902 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029844
 protein coding gene Chr5:109764526-109773896 (-)
A/J MGP_AJ_G0029808
 protein coding gene Chr5:105551734-105561110 (-)
AKR/J MGP_AKRJ_G0029753
 protein coding gene Chr5:108961818-108971186 (-)
BALB/cJ MGP_BALBcJ_G0029820
 protein coding gene Chr5:106684492-106694296 (-)
C3H/HeJ MGP_C3HHeJ_G0029542
 protein coding gene Chr5:109405333-109414687 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030274
 protein coding gene Chr5:114253458-114263784 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027508
 protein coding gene Chr5:100613340-100622733 (-)
CAST/EiJ MGP_CASTEiJ_G0028956
 protein coding gene Chr5:108345810-108355213 (-)
CBA/J MGP_CBAJ_G0029510
 protein coding gene Chr5:118106788-118116112 (-)
DBA/2J MGP_DBA2J_G0029656
 protein coding gene Chr5:105687726-105697094 (-)
FVB/NJ MGP_FVBNJ_G0029613
 protein coding gene Chr5:104417529-104426860 (-)
LP/J MGP_LPJ_G0029744
 protein coding gene Chr5:110349840-110360999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029645
 protein coding gene Chr5:123002892-123013362 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030308
 protein coding gene Chr5:108523059-108532464 (-)
PWK/PhJ MGP_PWKPhJ_G0028669
 protein coding gene Chr5:104494606-104504072 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028507
 protein coding gene Chr5:106035586-106045677 (-)
WSB/EiJ MGP_WSBEiJ_G0029029
 protein coding gene Chr5:108818524-108828631 (-)



Homology
more
  • Human Ortholog
    GFI1, growth factor independent 1 transcriptional repressor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GFI1, growth factor independent 1 transcriptional repressor
  • Synonyms
    GFI-1, GFI1A, SCN2, ZNF163
  • Links
    NCBI Gene ID: 2672
    neXtProt AC: NX_Q99684
    UniProt: Q99684

  • Chr Location
    1p22.1; chr1:92473043-92486925 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gfi1 mouse models; 2 with human GFI1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 10 alleles in 8 genetic backgrounds
    22 phenotypes from multigenic genotypes
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit loss of inner ear hair cells, ataxia, circling, and deafness. Mutants also show a block in granulocyte and neutrophil maturation, and are hypersensitive to endotoxin stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1097
  • Tissues
    213
  • cDNA Data
    14
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14581 NCBI Gene Model | MGI Sequence Detail 9151 C57BL/6J ±  kb
    transcript NM_010278 RefSeq | MGI Sequence Detail 2862 ZRU/MplStud  
    polypeptide P70338 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 19
      cDNA 16
      Primer pair 7
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13127, MGD-MRK-13128, MGD-MRK-24036, MGI:2141203, MGI:97474
    References
    more
    • Summaries
      All 226
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 15
      Phenotypes 144
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:360124 Hartig EI, et al., Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life. Proc Natl Acad Sci U S A. 2024 Oct;121(40):e2405455121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory