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Vegfa Gene Detail
Summary
  • Symbol
    Vegfa
  • Name
    vascular endothelial growth factor A
  • Synonyms
    Vegf, VEGF120, VEGF164, VEGF188, VEGF-A, VPF
  • Feature Type
    protein coding gene
  • IDs
    MGI:103178
    NCBI Gene: 22339
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:46327919-46343295 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    386 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103178
 protein coding gene Chr17:46327919-46343303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023800
 protein coding gene Chr17:47059017-47074394 (-)
A/J MGP_AJ_G0023758
 protein coding gene Chr17:45924795-45940178 (-)
AKR/J MGP_AKRJ_G0023729
 protein coding gene Chr17:46256056-46271436 (-)
BALB/cJ MGP_BALBcJ_G0023762
 protein coding gene Chr17:45814400-45829773 (-)
C3H/HeJ MGP_C3HHeJ_G0023526
 protein coding gene Chr17:46981973-46998185 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024205
 protein coding gene Chr17:49098338-49113975 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021655
 protein coding gene Chr17:42722585-42738015 (-)
CAST/EiJ MGP_CASTEiJ_G0023007
 protein coding gene Chr17:47099580-47116223 (-)
CBA/J MGP_CBAJ_G0023502
 protein coding gene Chr17:50840515-50859623 (-)
DBA/2J MGP_DBA2J_G0023628
 protein coding gene Chr17:44715543-44731300 (-)
FVB/NJ MGP_FVBNJ_G0023595
 protein coding gene Chr17:44315347-44331295 (-)
LP/J MGP_LPJ_G0023709
 protein coding gene Chr17:47714889-47732130 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023624
 protein coding gene Chr17:50402375-50419347 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024250
 protein coding gene Chr17:46610274-46625656 (-)
PWK/PhJ MGP_PWKPhJ_G0022752
 protein coding gene Chr17:44025676-44041852 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022567
 protein coding gene Chr17:43499989-43518065 (-)
WSB/EiJ MGP_WSBEiJ_G0023072
 protein coding gene Chr17:47152841-47170978 (-)



Homology
more
  • Human Ortholog
    VEGFA, vascular endothelial growth factor A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VEGFA, vascular endothelial growth factor A
  • Synonyms
    L-VEGF, MVCD1, VEGF, VPF
  • Links
    NCBI Gene ID: 7422
    neXtProt AC: NX_P15692
    UniProt: P15692

  • Chr Location
    6p21.1; chr6:43770184-43786487 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Vegfa mouse models; 25 with human VEGFA associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 2 models
IDs
 View 1 model
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    279 phenotypes from 15 alleles in 23 genetic backgrounds
    17 phenotypes from multigenic genotypes
    279 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hetero- or homozygous null mutants show embryonic lethality with impaired angiogenesis and blood-island formation. Mutants selectively expressing isoform 120 or 188 exhibit vascular outgrowth/patterning defects or impaired arterial development, respectively.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    304
  • GO References
    59
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1749
  • Tissues
    470
  • cDNA Data
    90
  • Literature Summary
    531
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023951 Ensembl Gene Model | MGI Sequence Detail 15377 C57BL/6J ±  kb
    transcript ENSMUST00000142351 Ensembl | MGI Sequence Detail 1973 Not Applicable  
    polypeptide ENSMUSP00000115883 Ensembl | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000017284 vascular endothelial growth factor A, long form
      (term hierarchy)
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR000072 PDGF/VEGF domain
      IPR023581 Platelet-derived growth factor, conserved site
      IPR050507 Platelet-derived/Vascular endothelial growth factor
      IPR027928 Vascular endothelial growth factor, heparin-binding domain
      IPR036841 Vascular endothelial growth factor, heparin-binding domain superfamily
    • GlyGen
      Q00731 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 190
      Genomic 3
      cDNA 98
      Primer pair 69
      Other 20

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-24046
    References
    more
    • Summaries
      All 1163
      Developmental Gene Expression 531
      Diseases 4
      Gene Ontology 59
      Phenotypes 279
    • Earliest
      J:27451 Breier G, et al., Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development. 1992 Feb;114(2):521-32
    • Latest
      J:357812 Silva-Hucha S, et al., VEGF expression disparities in brainstem motor neurons of the SOD1(G93A) ALS model: Correlations with neuronal vulnerability. Neurotherapeutics. 2024 Apr;21(3):e00340
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory