Uimc1 MGI Mouse Gene Detail - MGI:103185 - ubiquitin interaction motif containing 1

Symbol

Uimc1
Name

ubiquitin interaction motif containing 1
Synonyms

9430016E08Rik, D330018D10Rik, D630032M02Rik, Rxrip110

Feature Type

protein coding gene
IDs

MGI:103185
NCBI Gene: 20184
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:55175693-55248113 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.80 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

1462 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103185	protein coding gene	Chr13:55175693-55248176 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020584	protein coding gene	Chr13:54463884-54547912 (-)
A/J	MGP_AJ_G0020538	protein coding gene	Chr13:52466922-52544425 (-)
AKR/J	MGP_AKRJ_G0020516	protein coding gene	Chr13:54003652-54082678 (-)
BALB/cJ	MGP_BALBcJ_G0020534	protein coding gene	Chr13:52697015-52777928 (-)
C3H/HeJ	MGP_C3HHeJ_G0020333	protein coding gene	Chr13:53822413-53907896 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020968	protein coding gene	Chr13:56127983-56210543 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018550	protein coding gene	Chr13:50441068-50509525 (-)
CAST/EiJ	MGP_CASTEiJ_G0019847	protein coding gene	Chr13:53914631-54001772 (-)
CBA/J	MGP_CBAJ_G0020293	protein coding gene	Chr13:58256379-58344388 (-)
DBA/2J	MGP_DBA2J_G0020416	protein coding gene	Chr13:52022081-52099530 (-)
FVB/NJ	MGP_FVBNJ_G0020395	protein coding gene	Chr13:51486690-51562314 (-)
LP/J	MGP_LPJ_G0020492	protein coding gene	Chr13:54738751-54822099 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020424	protein coding gene	Chr13:57759069-57845087 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021011	protein coding gene	Chr13:53591595-53669868 (-)
PWK/PhJ	MGP_PWKPhJ_G0019603	protein coding gene	Chr13:52017421-52115241 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019430	protein coding gene	Chr13:52525357-52597163 (-)
WSB/EiJ	MGP_WSBEiJ_G0019909	protein coding gene	Chr13:53935223-54021970 (-)

Human Ortholog

UIMC1, ubiquitin interaction motif containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UIMC1, ubiquitin interaction motif containing 1
Synonyms

RAP80, X2HRIP110
Links

HGNC:30298

NCBI Gene ID: 51720

neXtProt AC: NX_Q96RL1

UniProt: Q96RL1
Chr Location

5q35.2; chr5:176905005-177022633 (-) GRCh38

MGI Vertebrate Homology

Uimc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UIMC1
Gene Tree

Uimc1

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References

1 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Targeted

5
Genomic Mutations

2 involving Uimc1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit premature death due to B-cell lymphomas and abnormal DNA repair.

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All GO Annotations

36
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

84

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase uimc1

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All Sequences

71
RefSeq

23
UniProt

6
CCDS

CCDS36671.1, CCDS79189.1

Ensembl

ENSMUSG00000025878 (Evidence)
NCBI Gene

20184

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025878	Ensembl Gene Model \| MGI Sequence Detail	72421	C57BL/6J	± kb
transcript	ENSMUST00000127195	Ensembl \| MGI Sequence Detail	2936	Not Applicable
polypeptide	ENSMUSP00000122196	Ensembl \| MGI Sequence Detail	727	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000029844 BRCA1-A complex subunit RAP80

(term hierarchy)
PDB

3A1Q, 6GVW
InterPro Domains

IPR038868 BRCA1-A complex subunit RAP80

IPR006642 Rad18, zinc finger UBZ4-type

IPR040714 RAP80, N-terminal

IPR003903 Ubiquitin interacting motif
GlyGen

Q5U5Q9 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 86

cDNA 86

Microarray probesets 3

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MGD-MRK-24053, MGI:1924548, MGI:2443168, MGI:2443285

Summaries

All 46

Diseases 1

Gene Ontology 9

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345315 Jiang Q, et al., Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition. J Cell Biol. 2022 Sep 5;221(9)

TSS for Uimc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122676	Chr13:55248061-55248134 (-)	15 bp
Tssr122675	Chr13:55248029-55248055 (-)	71 bp
Tssr122674	Chr13:55221609-55221624 (-)	26,496 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24