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Nfib Gene Detail
Summary
  • Symbol
    Nfib
  • Name
    nuclear factor I/B
  • Synonyms
    6720429L07Rik, E030026I10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:103188
    NCBI Gene: 18028
  • Alliance
    gene page
  • Transcription Start Sites
    38 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:82208410-82424988 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 38.40 cM, cytoband C4-C6
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4731 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103188
 protein coding gene Chr4:82208410-82623987 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028398
 protein coding gene Chr4:81851916-82275549 (-)
A/J MGP_AJ_G0028359
 protein coding gene Chr4:79027750-79439655 (-)
AKR/J MGP_AKRJ_G0028308
 protein coding gene Chr4:81065599-81483316 (-)
BALB/cJ MGP_BALBcJ_G0028379
 protein coding gene Chr4:79263739-79676624 (-)
C3H/HeJ MGP_C3HHeJ_G0028094
 protein coding gene Chr4:81629256-82082398 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028818
 protein coding gene Chr4:85116715-85537177 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026118
 protein coding gene Chr4:74991676-75406825 (-)
CAST/EiJ MGP_CASTEiJ_G0027535
 protein coding gene Chr4:79485158-79986530 (-)
CBA/J MGP_CBAJ_G0028063
 protein coding gene Chr4:87728445-88178185 (-)
DBA/2J MGP_DBA2J_G0028212
 protein coding gene Chr4:78808117-79217215 (-)
FVB/NJ MGP_FVBNJ_G0028178
 protein coding gene Chr4:77791587-78197016 (-)
LP/J MGP_LPJ_G0028312
 protein coding gene Chr4:82211307-82634152 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028207
 protein coding gene Chr4:92836606-93278220 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028855
 protein coding gene Chr4:81108170-81527407 (-)
PWK/PhJ MGP_PWKPhJ_G0027258
 protein coding gene Chr4:77114970-77556584 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027083
 protein coding gene Chr4:78640620-79080053 (-)
WSB/EiJ MGP_WSBEiJ_G0027611
 protein coding gene Chr4:81308708-81729434 (-)



Homology
more
  • Human Ortholog
    NFIB, nuclear factor I B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFIB, nuclear factor I B
  • Synonyms
    CTF, HMGIC/NFIB, MACID, NF1-B, NF-I/B, NFI-B, NFIB2, NFIB3, NFI-RED
  • Links
    NCBI Gene ID: 4781
    neXtProt AC: NX_O00712
    UniProt: O00712

  • Chr Location
    9p23-p22.3; chr9:14081843-14532077 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 3 alleles in 7 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes severe lung defects and neonatal death from respiratory failure. Homozygotes for a null allele show callosal agenesis and abnormalities in forebrain, basilar pons, hippocampus, and submandibular gland development, as well as lung maturation defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1138
  • Tissues
    337
  • cDNA Data
    31
  • Literature Summary
    65
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18028 NCBI Gene Model | MGI Sequence Detail 216579 C57BL/6J ±  kb
    transcript NM_001113209 RefSeq | MGI Sequence Detail 8841 C57BL/6  
    polypeptide P97863 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000011174 nuclear factor 1 B-type
      (term hierarchy)
    • InterPro Domains
      IPR000647 CTF transcription factor/nuclear factor 1
      IPR019739 CTF transcription factor/nuclear factor 1, conserved site
      IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
      IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
      IPR003619 MAD homology 1, Dwarfin-type
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 39
      Primer pair 5
      Other 5

      Microarray probesets 15
    Other
    Accession IDs
    less
    MGD-MRK-24056, MGI:1924433, MGI:2442665
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 65
      Gene Ontology 21
      Phenotypes 42
    • Earliest
      J:34412 Qian F, et al., Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH. Genomics. 1995 Jul 1;28(1):66-73
    • Latest
      J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory