Slc17a1 MGI Mouse Gene Detail - MGI:103209 - solute carrier family 17 (sodium phosphate), member 1

Symbol

Slc17a1
Name

solute carrier family 17 (sodium phosphate), member 1
Synonyms

NAPI-1, Npt1

Feature Type

protein coding gene
IDs

MGI:103209
NCBI Gene: 20504
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:24051733-24079713 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 9.97 cM, cytoband A3-A4
Mapping Data

4 experiments

SNPs within 2kb

916 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103209	protein coding gene	Chr13:24051607-24079713 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020371	protein coding gene	Chr13:21316265-21343639 (+)
A/J	MGP_AJ_G0020320	protein coding gene	Chr13:20922467-20949396 (+)
AKR/J	MGP_AKRJ_G0020300	protein coding gene	Chr13:21178212-21203002 (+)
BALB/cJ	MGP_BALBcJ_G0020318	protein coding gene	Chr13:20918375-20943228 (+)
C3H/HeJ	MGP_C3HHeJ_G0020122	protein coding gene	Chr13:21248988-21275476 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020755	protein coding gene	Chr13:22095680-22122758 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018343	protein coding gene	Chr13:19697971-19725232 (+)
CAST/EiJ	MGP_CASTEiJ_G0019639	protein coding gene	Chr13:20933607-20962301 (+)
CBA/J	MGP_CBAJ_G0020076	protein coding gene	Chr13:22951872-22981402 (+)
DBA/2J	MGP_DBA2J_G0020202	protein coding gene	Chr13:20449278-20474102 (+)
FVB/NJ	MGP_FVBNJ_G0020186	protein coding gene	Chr13:20100684-20125395 (+)
LP/J	MGP_LPJ_G0020275	protein coding gene	Chr13:21625186-21650189 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020213	protein coding gene	Chr13:23247513-23276512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020797	protein coding gene	Chr13:21027148-21053782 (+)
PWK/PhJ	MGP_PWKPhJ_G0019393	protein coding gene	Chr13:20482933-20510690 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019210	protein coding gene	Chr13:19840249-19867915 (+)
WSB/EiJ	MGP_WSBEiJ_G0019699	protein coding gene	Chr13:21170066-21199505 (+)

Human Ortholog

SLC17A1, solute carrier family 17 member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC17A1, solute carrier family 17 member 1
Synonyms

NAPI-1, NPT-1, NPT1
Links

HGNC:10929

NCBI Gene ID: 6568

neXtProt AC: NX_Q14916

UniProt: Q14916
Chr Location

6p22.2; chr6:25723743-25832052 (-) GRCh38

MGI Vertebrate Homology

Slc17a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC17A1
Gene Tree

Slc17a1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Genomic Mutations

2 involving Slc17a1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

9
cDNA Data

90
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

9
UniProt

3
CCDS

CCDS26372.1

Ensembl

ENSMUSG00000021335 (Evidence)
NCBI Gene

20504

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021335	Ensembl Gene Model \| MGI Sequence Detail	27981	C57BL/6J	± kb
transcript	ENSMUST00000110413	Ensembl \| MGI Sequence Detail	1965	Not Applicable
polypeptide	ENSMUSP00000106043	Ensembl \| MGI Sequence Detail	465	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014958 sodium-dependent phosphate transport protein 1

(term hierarchy)
InterPro Domains

IPR011701 Major facilitator superfamily

IPR020846 Major facilitator superfamily domain

IPR050382 Major Facilitator Superfamily Sodium/Anion Cotransporter

IPR036259 MFS transporter superfamily

IPR004745 Na-dependent inorganic phosphate cotransporter
GlyGen

Q61983 3 sites

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All nucleic 94

cDNA 90

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-24077

Summaries

All 52

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:355751 Li VL, et al., SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. Nat Commun. 2024 Aug 12;15(1):6895

TSS for Slc17a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4013	Chr13:24051966-24051996 (+)	248 bp
Tssr118879	Chr13:24054242-24054249 (+)	2,513 bp
Tssr118880	Chr13:24054267-24054291 (+)	2,546 bp
Tssr118881	Chr13:24064865-24064867 (+)	13,133 bp
Tssr118882	Chr13:24076790-24076801 (+)	25,063 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24