Fdx1 MGI Mouse Gene Detail - MGI:103224

Symbol

Fdx1
Name

ferredoxin 1
Synonyms

ADRENODOXIN

Feature Type

protein coding gene
IDs

MGI:103224
NCBI Gene: 14148
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:51854606-51874856 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 28.62 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

477 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103224	protein coding gene	Chr9:51854323-51874902 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034803	protein coding gene	Chr9:50902943-50923177 (-)
A/J	MGP_AJ_G0034784	protein coding gene	Chr9:49326772-49347006 (-)
AKR/J	MGP_AKRJ_G0034712	protein coding gene	Chr9:50371939-50392154 (-)
BALB/cJ	MGP_BALBcJ_G0034776	protein coding gene	Chr9:49083766-49104000 (-)
C3H/HeJ	MGP_C3HHeJ_G0034486	protein coding gene	Chr9:50868194-50888428 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035295	protein coding gene	Chr9:52325171-52345382 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032208	protein coding gene	Chr9:48770337-48792215 (-)
CAST/EiJ	MGP_CASTEiJ_G0033808	protein coding gene	Chr9:50831121-50851315 (-)
CBA/J	MGP_CBAJ_G0034457	protein coding gene	Chr9:54149384-54169591 (-)
DBA/2J	MGP_DBA2J_G0034616	protein coding gene	Chr9:49186661-49206895 (-)
FVB/NJ	MGP_FVBNJ_G0034558	protein coding gene	Chr9:48401937-48422311 (-)
LP/J	MGP_LPJ_G0034698	protein coding gene	Chr9:51241478-51263955 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034601	protein coding gene	Chr9:55736985-55757219 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035317	protein coding gene	Chr9:50370692-50390911 (-)
PWK/PhJ	MGP_PWKPhJ_G0033512	protein coding gene	Chr9:49174002-49196865 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033348	protein coding gene	Chr9:50642368-50666182 (-)
WSB/EiJ	MGP_WSBEiJ_G0033920	protein coding gene	Chr9:50366710-50386945 (-)

Human Ortholog

FDX1, ferredoxin 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FDX1, ferredoxin 1
Synonyms

ADX, FDX, LOH11CR1D
Links

HGNC:3638

NCBI Gene ID: 2230

neXtProt AC: NX_P10109

UniProt: P10109
Chr Location

11q22.3; chr11:110429331-110464884 (+) GRCh38

MGI Vertebrate Homology

Fdx1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FDX1
Gene Tree

Fdx1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

9
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fdx1

ZFIN fdx1, fdx1b

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All Sequences

48
RefSeq

4
UniProt

6
CCDS

CCDS23178.1, CCDS90568.1

Ensembl

ENSMUSG00000032051 (Evidence)
NCBI Gene

14148

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032051	Ensembl Gene Model \| MGI Sequence Detail	20251	C57BL/6J	± kb
transcript	ENSMUST00000034552	Ensembl \| MGI Sequence Detail	875	Not Applicable
polypeptide	ENSMUSP00000034552	Ensembl \| MGI Sequence Detail	188	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007450 adrenodoxin, mitochondrial

(term hierarchy)
InterPro Domains

IPR036010 2Fe-2S ferredoxin-like superfamily

IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain

IPR018298 Adrenodoxin, iron-sulphur binding site

IPR001055 Adrenodoxin-like

IPR012675 Beta-grasp domain superfamily
GlyGen

P46656 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

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MGD-MRK-24095

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 12
Earliest

J:23742 Stromstedt M, et al., A full-length cDNA encoding mouse adrenodoxin. Biochim Biophys Acta. 1995 Mar 14;1261(1):126-8
Latest

J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;

TSS for Fdx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr89557	Chr9:51874909-51874916 (-)	-57 bp
Tssr89556	Chr9:51874848-51874863 (-)	0 bp
Tssr89555	Chr9:51874770-51874825 (-)	58 bp
Tssr89554	Chr9:51874704-51874725 (-)	141 bp
Tssr89553	Chr9:51868233-51868236 (-)	6,621 bp
Tssr89552	Chr9:51857143-51857146 (-)	17,711 bp
Tssr89551	Chr9:51854671-51854675 (-)	20,183 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24