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Yap1 Gene Detail
Summary
  • Symbol
    Yap1
  • Name
    yes-associated protein 1
  • Synonyms
    Yap, Yki, yorkie
  • Feature Type
    protein coding gene
  • IDs
    MGI:103262
    NCBI Gene: 22601
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7932000-8004597 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1785 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103262
 protein coding gene Chr9:7932000-8004890 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034331
 protein coding gene Chr9:4808131-4899209 (-)
A/J MGP_AJ_G0034309
 protein coding gene Chr9:4916435-4990278 (-)
AKR/J MGP_AKRJ_G0034237
 protein coding gene Chr9:4784660-4863767 (-)
BALB/cJ MGP_BALBcJ_G0034303
 protein coding gene Chr9:4646362-4725577 (-)
C3H/HeJ MGP_C3HHeJ_G0034014
 protein coding gene Chr9:4961444-5041039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034825
 protein coding gene Chr9:4982387-5064884 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031763
 protein coding gene Chr9:4148970-4222765 (-)
CAST/EiJ MGP_CASTEiJ_G0033342
 protein coding gene Chr9:4987473-5062756 (-)
CBA/J MGP_CBAJ_G0033987
 protein coding gene Chr9:5146299-5240695 (-)
DBA/2J MGP_DBA2J_G0034144
 protein coding gene Chr9:4774394-4859344 (-)
FVB/NJ MGP_FVBNJ_G0034089
 protein coding gene Chr9:4557731-4630890 (-)
LP/J MGP_LPJ_G0034230
 protein coding gene Chr9:4853395-4928172 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034133
 protein coding gene Chr9:5853465-5936876 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034844
 protein coding gene Chr9:4779698-4861675 (-)
PWK/PhJ MGP_PWKPhJ_G0033045
 protein coding gene Chr9:4899821-4978365 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032883
 protein coding gene Chr9:5027179-5099557 (-)
WSB/EiJ MGP_WSBEiJ_G0033457
 protein coding gene Chr9:4810366-4887607 (-)



Homology
more
  • Human Ortholog
    YAP1, Yes1 associated transcriptional regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YAP1, Yes1 associated transcriptional regulator
  • Synonyms
    COB1, YAP, YAP-1, YAP2, YAP65, YKI
  • Links
    NCBI Gene ID: 10413
    neXtProt AC: NX_P46937
    UniProt: P46937

  • Chr Location
    11q22.1; chr11:102110447-102233424 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Yap1 mouse models; 1 with human YAP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    92 phenotypes from 12 alleles in 13 genetic backgrounds
    31 phenotypes from multigenic genotypes
    12 images
    334 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null mutation of this gene die between embryonic days E9.5 and E10.5 due to yolk sac avasculogenesis and failure of attachment between the allantois and the chorion. Heterozygous mice are viable, and fertile but exhibit age-dependent cone photoreceptor degeneration and retinal abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    154
  • GO References
    46
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1127
  • Tissues
    175
  • cDNA Data
    15
  • Literature Summary
    204
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053110 Ensembl Gene Model | MGI Sequence Detail 72598 C57BL/6J ±  kb
    transcript ENSMUST00000065353 Ensembl | MGI Sequence Detail 4171 Not Applicable  
    polypeptide ENSMUSP00000069554 Ensembl | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 16
      Primer pair 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24140, MGI:2143022
    References
    more
    • Summaries
      All 644
      Developmental Gene Expression 204
      Diseases 1
      Gene Ontology 46
      Phenotypes 334
    • Earliest
      J:26090 Sudol M, et al., Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem. 1995 Jun 16;270(24):14733-41
    • Latest
      J:359562 Ye S, et al., YAP1 preserves tubular mitochondrial quality control to mitigate diabetic kidney disease. Redox Biol. 2024 Dec;78:103435
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory