Frk MGI Mouse Gene Detail - MGI:103265

Symbol

Frk
Name

fyn-related kinase
Synonyms

BSK/IYK, GTK

Feature Type

protein coding gene
IDs

MGI:103265
NCBI Gene: 14302
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:34359395-34487274 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 18.85 cM
Mapping Data

2 experiments

SNPs within 2kb

3508 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103265	protein coding gene	Chr10:34359395-34487530 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017142	protein coding gene	Chr10:32825834-32961121 (+)
A/J	MGP_AJ_G0017119	protein coding gene	Chr10:31981432-32109823 (+)
AKR/J	MGP_AKRJ_G0017079	protein coding gene	Chr10:32361750-32493204 (+)
BALB/cJ	MGP_BALBcJ_G0017082	protein coding gene	Chr10:31913781-32046090 (+)
C3H/HeJ	MGP_C3HHeJ_G0016902	protein coding gene	Chr10:32656466-32787620 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017540	protein coding gene	Chr10:33777907-33914376 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015237	protein coding gene	Chr10:30285097-30405668 (+)
CAST/EiJ	MGP_CASTEiJ_G0016481	protein coding gene	Chr10:32772283-32912532 (+)
CBA/J	MGP_CBAJ_G0016876	protein coding gene	Chr10:35406741-35552202 (+)
DBA/2J	MGP_DBA2J_G0016981	protein coding gene	Chr10:31550058-31676795 (+)
FVB/NJ	MGP_FVBNJ_G0016976	protein coding gene	Chr10:31065342-31193868 (+)
LP/J	MGP_LPJ_G0017058	protein coding gene	Chr10:32828815-32965241 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017006	protein coding gene	Chr10:35872444-36015058 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017576	protein coding gene	Chr10:32306683-32446275 (+)
PWK/PhJ	MGP_PWKPhJ_G0016262	protein coding gene	Chr10:31323997-31456276 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016046	protein coding gene	Chr10:32170416-32306316 (+)
WSB/EiJ	MGP_WSBEiJ_G0016544	protein coding gene	Chr10:32578842-32716845 (+)

Human Ortholog

FRK, fyn related Src family tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FRK, fyn related Src family tyrosine kinase
Synonyms

GTK, PTK5, RAK
Links

HGNC:3955

NCBI Gene ID: 2444

neXtProt AC: NX_P42685

UniProt: P42685
Chr Location

6q22.1; chr6:115931149-116100725 (-) GRCh38

MGI Vertebrate Homology

Frk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FRK
Gene Tree

Frk

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Frk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation do not exhibit increased susceptibility to spontaneous tumors nor increased sensitivity to inoizing radiation. Epithelial tissues appear similar to controls, but circulating levels of T3 were significantly reduced.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1082
Tissues

116
cDNA Data

32
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FRK

Xenbase frk

ZFIN frk

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All Sequences

53
RefSeq

10
UniProt

1
CCDS

CCDS23781.1

Ensembl

ENSMUSG00000019779 (Evidence)
NCBI Gene

14302

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019779	Ensembl Gene Model \| MGI Sequence Detail	127880	C57BL/6J	± kb
transcript	ENSMUST00000019913	Ensembl \| MGI Sequence Detail	4696	Not Applicable
polypeptide	ENSMUSP00000019913	Ensembl \| MGI Sequence Detail	512	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007664 tyrosine-protein kinase FRK

(term hierarchy)
PDB

2D8J, 2DLY
EC

2.7.10.2
InterPro Domains

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR035805 Tyrosine-protein kinase Frk, SH2 domain

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All nucleic 36

cDNA 34

Primer pair 2

Microarray probesets 5

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MGD-MRK-24144, MGI:2143937

Summaries

All 55

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 19
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Frk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92935	Chr10:34359411-34359441 (+)	31 bp
Tssr92936	Chr10:34359446-34359475 (+)	66 bp
Tssr92937	Chr10:34359513-34359529 (+)	126 bp
Tssr92938	Chr10:34359542-34359595 (+)	174 bp
Tssr92939	Chr10:34359626-34359640 (+)	238 bp
Tssr92940	Chr10:34360842-34360846 (+)	1,449 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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