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Rela Gene Detail
Summary
  • Symbol
    Rela
  • Name
    v-rel reticuloendotheliosis viral oncogene homolog A (avian)
  • Synonyms
    p65, p65 NF kappaB
  • Feature Type
    protein coding gene
  • IDs
    MGI:103290
    NCBI Gene: 19697
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:5687511-5698158 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband B1-3
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    346 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103290
 protein coding gene Chr19:5686993-5698162 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024719
 protein coding gene Chr19:2622628-2633275 (+)
A/J MGP_AJ_G0024685
 protein coding gene Chr19:2476588-2487247 (+)
AKR/J MGP_AKRJ_G0024658
 protein coding gene Chr19:2543374-2554033 (+)
BALB/cJ MGP_BALBcJ_G0024685
 protein coding gene Chr19:2470538-2481231 (+)
C3H/HeJ MGP_C3HHeJ_G0024453
 protein coding gene Chr19:2558909-2569558 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025132
 protein coding gene Chr19:2688916-2699563 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022562
 protein coding gene Chr19:2386340-2396786 (+)
CAST/EiJ MGP_CASTEiJ_G0023925
 protein coding gene Chr19:2579520-2589492 (+)
CBA/J MGP_CBAJ_G0024425
 protein coding gene Chr19:2809965-2820601 (+)
DBA/2J MGP_DBA2J_G0024552
 protein coding gene Chr19:2472292-2482906 (+)
FVB/NJ MGP_FVBNJ_G0024518
 protein coding gene Chr19:2465368-2476961 (+)
LP/J MGP_LPJ_G0024638
 protein coding gene Chr19:2596851-2607498 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024548
 protein coding gene Chr19:2656695-2667354 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025180
 protein coding gene Chr19:2563443-2574690 (+)
PWK/PhJ MGP_PWKPhJ_G0023671
 protein coding gene Chr19:2494829-2505475 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023476
 protein coding gene Chr19:2546522-2557143 (+)
WSB/EiJ MGP_WSBEiJ_G0023987
 protein coding gene Chr19:2573516-2584164 (+)



Homology
more
  • Human Ortholog
    RELA, RELA proto-oncogene, NF-kB subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RELA, RELA proto-oncogene, NF-kB subunit
  • Synonyms
    AIF3BL3, CMCU, NFKB3, p65
  • Links
    NCBI Gene ID: 5970
    neXtProt AC: NX_Q04206
    UniProt: Q04206

  • Chr Location
    11q13.1; chr11:65653599-65663857 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human RELA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 10 alleles in 12 genetic backgrounds
    56 phenotypes from multigenic genotypes
    198 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are embryonic lethal due to hepatic apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    252
  • GO References
    87
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1184
  • Tissues
    136
  • cDNA Data
    143
  • Literature Summary
    62
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024927 Ensembl Gene Model | MGI Sequence Detail 10648 C57BL/6J ±  kb
    transcript ENSMUST00000025867 Ensembl | MGI Sequence Detail 2716 Not Applicable  
    polypeptide ENSMUSP00000025867 Ensembl | MGI Sequence Detail 549 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 5
      cDNA 143
      Primer pair 7
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24172
    References
    more
    • Summaries
      All 580
      Developmental Gene Expression 62
      Gene Ontology 87
      Phenotypes 198
    • Earliest
      J:35636 Nolan GP, et al., DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell. 1991 Mar 8;64(5):961-9
    • Latest
      J:352326 Jovasevic V, et al., Formation of memory assemblies through the DNA-sensing TLR9 pathway. Nature. 2024 Apr;628(8006):145-153
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory