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Nfatc3 Gene Detail
Summary
  • Symbol
    Nfatc3
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
  • Synonyms
    D8Ertd281e, NFAT4, NFATx
  • Feature Type
    protein coding gene
  • IDs
    MGI:103296
    NCBI Gene: 18021
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106785472-106857169 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.08 cM, cytoband D
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103296
 protein coding gene Chr8:106785450-106857169 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034075
 protein coding gene Chr8:108399051-108474197 (+)
A/J MGP_AJ_G0034056
 protein coding gene Chr8:104061625-104138948 (+)
AKR/J MGP_AKRJ_G0033982
 protein coding gene Chr8:107062987-107147372 (+)
BALB/cJ MGP_BALBcJ_G0034049
 protein coding gene Chr8:104244681-104320027 (+)
C3H/HeJ MGP_C3HHeJ_G0033761
 protein coding gene Chr8:107807158-107886652 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034569
 protein coding gene Chr8:112364142-112453585 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031511
 protein coding gene Chr8:97191565-97269227 (+)
CAST/EiJ MGP_CASTEiJ_G0033087
 protein coding gene Chr8:107336532-107413438 (+)
CBA/J MGP_CBAJ_G0033734
 protein coding gene Chr8:115987092-116066644 (+)
DBA/2J MGP_DBA2J_G0033889
 protein coding gene Chr8:103402876-103475565 (+)
FVB/NJ MGP_FVBNJ_G0033834
 protein coding gene Chr8:102337701-102408951 (+)
LP/J MGP_LPJ_G0033980
 protein coding gene Chr8:108609081-108685782 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033878
 protein coding gene Chr8:119160712-119253685 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034587
 protein coding gene Chr8:107036546-107114762 (+)
PWK/PhJ MGP_PWKPhJ_G0032788
 protein coding gene Chr8:102810553-102887387 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032629
 protein coding gene Chr8:105735965-105810091 (+)
WSB/EiJ MGP_WSBEiJ_G0033203
 protein coding gene Chr8:107726876-107801681 (+)



Homology
more
  • Human Ortholog
    NFATC3, nuclear factor of activated T cells 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFATC3, nuclear factor of activated T cells 3
  • Synonyms
    n339260, NFAT4, NF-AT4c, NFATX
  • Links
    NCBI Gene ID: 4775
    neXtProt AC: NX_Q12968
    UniProt: Q12968

  • Chr Location
    16q22.1; chr16:68084751-68229259 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 5 genetic backgrounds
    52 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene experience some embryonic lethality and reduced body size. Developmental defects also exist in the immune system , skeletal muscle, vasculature, heart, and sensory nerves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    958
  • Tissues
    206
  • cDNA Data
    141
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031902 Ensembl Gene Model | MGI Sequence Detail 71698 C57BL/6J ±  kb
    transcript ENSMUST00000109308 Ensembl | MGI Sequence Detail 5984 Not Applicable  
    polypeptide ENSMUSP00000104931 Ensembl | MGI Sequence Detail 1076 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000011166 nuclear factor of activated T-cells, cytoplasmic 3
      (term hierarchy)
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002909 IPT domain
      IPR008366 Nuclear factor of activated T cells (NFAT)
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR032397 Rel homology dimerisation domain
      IPR011539 Rel homology domain, DNA-binding domain
      IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 153
      cDNA 145
      Primer pair 6
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24179, MGI:1098734, MGI:2142861
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 34
      Phenotypes 60
    • Earliest
      J:24518 Lin X, et al., Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol Cell Biol. 1995 May;15(5):2754-62
    • Latest
      J:346703 Bulow S, et al., Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response. Cell Rep. 2024 Mar 26;43(3):113929
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory