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Rbl1 Gene Detail
Summary
  • Symbol
    Rbl1
  • Name
    RB transcriptional corepressor like 1
  • Synonyms
    p107, retinoblastoma-like 1 (p107)
  • Feature Type
    protein coding gene
  • IDs
    MGI:103300
    NCBI Gene: 19650
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:156987813-157046454 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.05 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1498 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103300
 protein coding gene Chr2:156987813-157046454 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026777
 protein coding gene Chr2:162128018-162186927 (-)
A/J MGP_AJ_G0026743
 protein coding gene Chr2:155645628-155707977 (-)
AKR/J MGP_AKRJ_G0026714
 protein coding gene Chr2:160222088-160285826 (-)
BALB/cJ MGP_BALBcJ_G0026752
 protein coding gene Chr2:155931292-155995401 (-)
C3H/HeJ MGP_C3HHeJ_G0026494
 protein coding gene Chr2:160522305-160588286 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027201
 protein coding gene Chr2:166920428-166986506 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024571
 protein coding gene Chr2:149109117-149164820 (-)
CAST/EiJ MGP_CASTEiJ_G0025956
 protein coding gene Chr2:160875607-160937268 (-)
CBA/J MGP_CBAJ_G0026471
 protein coding gene Chr2:172954525-173020186 (-)
DBA/2J MGP_DBA2J_G0026609
 protein coding gene Chr2:154817146-154877980 (-)
FVB/NJ MGP_FVBNJ_G0026576
 protein coding gene Chr2:153216856-153277449 (-)
LP/J MGP_LPJ_G0026714
 protein coding gene Chr2:162221062-162291284 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026597
 protein coding gene Chr2:176798599-176879510 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027257
 protein coding gene Chr2:160038822-160101819 (-)
PWK/PhJ MGP_PWKPhJ_G0025690
 protein coding gene Chr2:154328819-154399141 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025493
 protein coding gene Chr2:158990428-159052756 (-)
WSB/EiJ MGP_WSBEiJ_G0026026
 protein coding gene Chr2:160928793-160992989 (-)



Homology
more
  • Human Ortholog
    RBL1, RB transcriptional corepressor like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBL1, RB transcriptional corepressor like 1
  • Synonyms
    CP107, p107, PRB1
  • Links
    NCBI Gene ID: 5933
    neXtProt AC: NX_P28749
    UniProt: P28749

  • Chr Location
    20q11.23; chr20:36996349-37095997 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 6 alleles in 11 genetic backgrounds
    107 phenotypes from multigenic genotypes
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are viable and fertile, but may show impaired growth, myeloid hyperplasia in spleen and liver and give rise to cells with a 2X doubling time in vitro. These effects are genetic background dependent.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    891
  • Tissues
    107
  • cDNA Data
    26
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19650 NCBI Gene Model | MGI Sequence Detail 58642 C57BL/6J ±  kb
    transcript NM_011249 RefSeq | MGI Sequence Detail 4909 ZRU/MplStud  
    polypeptide Q64701 UniProt | EBI | MGI Sequence Detail 1063 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 29
      Primer pair 9

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24184, MGI:2139378
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 37
      Diseases 3
      Gene Ontology 12
      Phenotypes 102
    • Earliest
      J:18604 Schneider JW, et al., Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science. 1994 Jun 3;264(5164):1467-71
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory