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Alk Gene Detail
Summary
  • Symbol
    Alk
  • Name
    anaplastic lymphoma kinase
  • Synonyms
    CD246, Tcrz
  • Feature Type
    protein coding gene
  • IDs
    MGI:103305
    NCBI Gene: 11682
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:72175967-72911622 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 43.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    22390 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103305
 protein coding gene Chr17:72174206-72911719 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024015
 protein coding gene Chr17:74348368-75118860 (-)
A/J MGP_AJ_G0023973
 protein coding gene Chr17:72094372-72839287 (-)
AKR/J MGP_AKRJ_G0023942
 protein coding gene Chr17:73092378-73847941 (-)
BALB/cJ MGP_BALBcJ_G0023974
 protein coding gene Chr17:72027615-72767342 (-)
C3H/HeJ MGP_C3HHeJ_G0023738
 protein coding gene Chr17:74026872-74791701 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024420
 protein coding gene Chr17:77057089-77846305 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021865
 protein coding gene Chr17:67841714-68558250 (-)
CAST/EiJ MGP_CASTEiJ_G0023219
 protein coding gene Chr17:74485907-75247414 (-)
CBA/J MGP_CBAJ_G0023713
 protein coding gene Chr17:80258819-81054477 (-)
DBA/2J MGP_DBA2J_G0023842
 protein coding gene Chr17:70750101-71481530 (-)
FVB/NJ MGP_FVBNJ_G0023808
 protein coding gene Chr17:70227017-70955850 (-)
LP/J MGP_LPJ_G0023924
 protein coding gene Chr17:75085477-75877629 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023836
 protein coding gene Chr17:80131944-80928146 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024464
 protein coding gene Chr17:73596539-74353261 (-)
PWK/PhJ MGP_PWKPhJ_G0022965
 protein coding gene Chr17:70072975-70800182 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022776
 protein coding gene Chr17:70307138-71043595 (-)
WSB/EiJ MGP_WSBEiJ_G0023286
 protein coding gene Chr17:74429602-75193629 (-)



Homology
more
  • Human Ortholog
    ALK, ALK receptor tyrosine kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALK, ALK receptor tyrosine kinase
  • Synonyms
    ALK1, CD246, NBLST3
  • Links
    NCBI Gene ID: 238
    neXtProt AC: NX_Q9UM73
    UniProt: Q9UM73

  • Chr Location
    2p23.2-p23.1; chr2:29192774-29921586 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 4 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased ethanol consumption and increased sedation in response to ethanol. Male mice homozygous for a different null allele show delayed puberty, hypogonadotropic hypogonadism, reduced serum testosterone levels, and altered seminiferous tubule morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1252
  • Tissues
    371
  • cDNA Data
    20
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055471 Ensembl Gene Model | MGI Sequence Detail 735656 C57BL/6J ±  kb
    transcript ENSMUST00000086639 Ensembl | MGI Sequence Detail 5454 Not Applicable  
    polypeptide ENSMUSP00000083840 Ensembl | MGI Sequence Detail 1621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000001282 ALK tyrosine kinase receptor
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR036055 LDL receptor-like superfamily
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR000998 MAM domain
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    • GlyGen
      P97793 16 sites, 5 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 3
      cDNA 20
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24189
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 16
      Phenotypes 21
    • Earliest
      J:38791 Fujita N, et al., Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse. FEBS Lett. 1988 May 23;232(2):323-7
    • Latest
      J:338243 Christova T, et al., LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity. EMBO Rep. 2023 Jul 5;24(7):e56937
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory