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Tiam1 Gene Detail
Summary
  • Symbol
    Tiam1
  • Name
    T cell lymphoma invasion and metastasis 1
  • Synonyms
    D16Ium10, D16Ium10e
  • Feature Type
    protein coding gene
  • IDs
    MGI:103306
    NCBI Gene: 21844
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:89583999-89940657 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.50 cM, cytoband C3-4
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10541 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103306
 protein coding gene Chr16:89583999-89942488 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023023
 protein coding gene Chr16:90680551-90876307 (-)
A/J MGP_AJ_G0022991
 protein coding gene Chr16:86461187-86653510 (-)
AKR/J MGP_AKRJ_G0022961
 protein coding gene Chr16:89082134-89268887 (-)
BALB/cJ MGP_BALBcJ_G0022993
 protein coding gene Chr16:86985985-87181311 (-)
C3H/HeJ MGP_C3HHeJ_G0022754
 protein coding gene Chr16:89621098-89827671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023440
 protein coding gene Chr16:93629380-93827704 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020942
 protein coding gene Chr16:84191451-84383305 (-)
CAST/EiJ MGP_CASTEiJ_G0022273
 protein coding gene Chr16:90128871-90338121 (-)
CBA/J MGP_CBAJ_G0022723
 protein coding gene Chr16:97614372-97822655 (-)
DBA/2J MGP_DBA2J_G0022857
 protein coding gene Chr16:86376547-86567274 (-)
FVB/NJ MGP_FVBNJ_G0022831
 protein coding gene Chr16:85492285-85684621 (-)
LP/J MGP_LPJ_G0022927
 protein coding gene Chr16:90378287-90577066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022852
 protein coding gene Chr16:102247669-102454183 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023458
 protein coding gene Chr16:89568008-89766732 (-)
PWK/PhJ MGP_PWKPhJ_G0022018
 protein coding gene Chr16:86492287-86708848 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021848
 protein coding gene Chr16:89099273-89302137 (-)
WSB/EiJ MGP_WSBEiJ_G0022325
 protein coding gene Chr16:89804550-90002417 (-)



Homology
more
  • Human Ortholog
    TIAM1, TIAM Rac1 associated GEF 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIAM1, TIAM Rac1 associated GEF 1
  • Synonyms
    NEDLDS, TIAM-1
  • Links
    NCBI Gene ID: 7074
    neXtProt AC: NX_Q13009
    UniProt: Q13009

  • Chr Location
    21q22.11; chr21:31118416-31559977 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TIAM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele display resistance to chemically-induced tumors, however, tumors that do develop progress to malignancy. Mice homozygous for a gene trap allele display anencephaly, exencephaly and/or neural tube defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    923
  • Tissues
    99
  • cDNA Data
    72
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002489 Ensembl Gene Model | MGI Sequence Detail 356659 C57BL/6J ±  kb
    transcript ENSMUST00000163370 Ensembl | MGI Sequence Detail 7255 Not Applicable  
    polypeptide ENSMUSP00000132137 Ensembl | MGI Sequence Detail 1591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 4
      cDNA 74
      Primer pair 2
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-24190, MGD-MRK-33864, MGI:106177, MGI:2146497
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 16
      Gene Ontology 11
      Phenotypes 38
    • Earliest
      J:18555 Habets GG, et al., Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins. Cell. 1994 May 20;77(4):537-49
    • Latest
      J:349355 Wu Y, et al., Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia. J Cell Mol Med. 2024 Jun;28(11):e18443
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory