Cacnb3 MGI Mouse Gene Detail - MGI:103307 - calcium channel, voltage-dependent, beta 3 subunit

Symbol

Cacnb3
Name

calcium channel, voltage-dependent, beta 3 subunit
Synonyms

Beta3, Cchb3

Feature Type

protein coding gene
IDs

MGI:103307
NCBI Gene: 12297
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:98528721-98542410 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 54.64 cM
Mapping Data

9 experiments

SNPs within 2kb

292 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103307	protein coding gene	Chr15:98526317-98542410 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022304	protein coding gene	Chr15:100379741-100392414 (+)
A/J	MGP_AJ_G0022262	protein coding gene	Chr15:96413755-96427989 (+)
AKR/J	MGP_AKRJ_G0022237	protein coding gene	Chr15:99382867-99396959 (+)
BALB/cJ	MGP_BALBcJ_G0022269	protein coding gene	Chr15:96612171-96625191 (+)
C3H/HeJ	MGP_C3HHeJ_G0022037	protein coding gene	Chr15:99424211-99437532 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022714	protein coding gene	Chr15:104098192-104110638 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020239	protein coding gene	Chr15:92332865-92345089 (+)
CAST/EiJ	MGP_CASTEiJ_G0021560	protein coding gene	Chr15:100280240-100292319 (+)
CBA/J	MGP_CBAJ_G0022006	protein coding gene	Chr15:107629462-107644864 (+)
DBA/2J	MGP_DBA2J_G0022132	protein coding gene	Chr15:95858743-95871047 (+)
FVB/NJ	MGP_FVBNJ_G0022112	protein coding gene	Chr15:94835664-94849194 (+)
LP/J	MGP_LPJ_G0022204	protein coding gene	Chr15:100530841-100543668 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022132	protein coding gene	Chr15:111656311-111669837 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022729	protein coding gene	Chr15:99460942-99475306 (+)
PWK/PhJ	MGP_PWKPhJ_G0021301	protein coding gene	Chr15:95977379-95990687 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021136	protein coding gene	Chr15:99307322-99319079 (+)
WSB/EiJ	MGP_WSBEiJ_G0021610	protein coding gene	Chr15:100007793-100020731 (+)

Human Ortholog

CACNB3, calcium voltage-gated channel auxiliary subunit beta 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CACNB3, calcium voltage-gated channel auxiliary subunit beta 3
Synonyms

CAB3, CACNLB3
Links

HGNC:1403

NCBI Gene ID: 784

neXtProt AC: NX_P54284

UniProt: P54284
Chr Location

12q13.12; chr12:48813794-48828941 (+) GRCh38

MGI Vertebrate Homology

Cacnb3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CACNB3
Gene Tree

Cacnb3

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References

1 with disease annotations

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Phenotype Summary

22 phenotypes from 2 alleles in 3 genetic backgrounds
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

8
Radiation induced

2
Targeted

5
Transgenic

1
Genomic Mutations

3 involving Cacnb3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show altered Ca2+ channel activity, hyporesponsiveness to DHP, high blood pressure on a high salt diet, and impaired calcium responses and cytokine production in CD4 T cells. Homozygotes for another null allele show enhancedNMDA activity and long term potentiation.

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All GO Annotations

39
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

874
Tissues

70
cDNA Data

101
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cacnb3

ZFIN cacnb3a, cacnb3b

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All Sequences

120
RefSeq

56
UniProt

4
CCDS

CCDS27800.1, CCDS37192.1, CCDS88834.1

Ensembl

ENSMUSG00000003352 (Evidence)
NCBI Gene

12297

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003352	Ensembl Gene Model \| MGI Sequence Detail	13690	C57BL/6J	± kb
transcript	ENSMUST00000230490	Ensembl \| MGI Sequence Detail	2477	Not Applicable
polypeptide	ENSMUSP00000155514	Ensembl \| MGI Sequence Detail	484	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004948 voltage-dependent L-type calcium channel subunit beta-3

(term hierarchy)
InterPro Domains

IPR008145 Guanylate kinase/L-type calcium channel beta subunit

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008079 Voltage-dependent calcium channel, L-type, beta-3 subunit

IPR000584 Voltage-dependent calcium channel, L-type, beta subunit

IPR046937 Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain

IPR035760 Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain
GlyGen

P54285 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 110

Genomic 4

cDNA 102

Primer pair 4

Microarray probesets 3

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MGD-MRK-24191

Summaries

All 92

Developmental Gene Expression 11

Diseases 1

Gene Ontology 8

Phenotypes 46
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cacnb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132952	Chr15:98530226-98530271 (+)	1,528 bp
Tssr132953	Chr15:98530274-98530292 (+)	1,562 bp
Tssr132954	Chr15:98532611-98532616 (+)	3,893 bp
Tssr132955	Chr15:98532624-98532659 (+)	3,921 bp
Tssr132956	Chr15:98532670-98532690 (+)	3,959 bp
Tssr132957	Chr15:98532868-98532956 (+)	4,191 bp
Tssr132958	Chr15:98541933-98541967 (+)	13,229 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24