Flot2 MGI Mouse Gene Detail - MGI:103309

Symbol

Flot2
Name

flotillin 2
Synonyms

Esa, reggie-2

Feature Type

protein coding gene
IDs

MGI:103309
NCBI Gene: 14252
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:77928757-77951260 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.74 cM
Mapping Data

3 experiments

SNPs within 2kb

612 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103309	protein coding gene	Chr11:77928757-77951260 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018761	protein coding gene	Chr11:78999919-79024795 (+)
A/J	MGP_AJ_G0018727	protein coding gene	Chr11:75993594-76016805 (+)
AKR/J	MGP_AKRJ_G0018697	protein coding gene	Chr11:78299948-78321757 (+)
BALB/cJ	MGP_BALBcJ_G0018701	protein coding gene	Chr11:76387585-76412611 (+)
C3H/HeJ	MGP_C3HHeJ_G0018514	protein coding gene	Chr11:78334048-78356950 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019152	protein coding gene	Chr11:81472276-81495718 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016787	protein coding gene	Chr11:72969862-72990181 (+)
CAST/EiJ	MGP_CASTEiJ_G0018068	protein coding gene	Chr11:78766211-78792614 (+)
CBA/J	MGP_CBAJ_G0018484	protein coding gene	Chr11:85025171-85050597 (+)
DBA/2J	MGP_DBA2J_G0018593	protein coding gene	Chr11:75576014-75598373 (+)
FVB/NJ	MGP_FVBNJ_G0018583	protein coding gene	Chr11:75158280-75182105 (+)
LP/J	MGP_LPJ_G0018664	protein coding gene	Chr11:79544127-79566957 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018609	protein coding gene	Chr11:85466596-85489832 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019192	protein coding gene	Chr11:78536831-78559146 (+)
PWK/PhJ	MGP_PWKPhJ_G0017839	protein coding gene	Chr11:76351310-76373887 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017630	protein coding gene	Chr11:78140676-78164583 (+)
WSB/EiJ	MGP_WSBEiJ_G0018121	protein coding gene	Chr11:78349077-78372400 (+)

Human Ortholog

FLOT2, flotillin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLOT2, flotillin 2
Synonyms

ECS-1, ECS1, ESA, ESA1, M17S1
Links

HGNC:3758

NCBI Gene ID: 2319

neXtProt AC: NX_Q14254

UniProt: Q14254
Chr Location

17q11.2; chr17:28879335-28897733 (-) GRCh38

MGI Vertebrate Homology

Flot2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FLOT2
Gene Tree

Flot2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

6
Genomic Mutations

2 involving Flot2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced metastasis into the lungs in a breast cancer model. Homozygous double KO with Flot1 increases susceptibility to induced necroptosis.

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All GO Annotations

66
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

51
cDNA Data

107
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FLOT2

Xenbase flot2

ZFIN flot2a

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All Sequences

90
RefSeq

20
UniProt

6
CCDS

CCDS25088.1, CCDS36237.1, CCDS88200.1

Ensembl

ENSMUSG00000061981 (Evidence)
NCBI Gene

14252

			Length	Strain/Species	Flank
genomic	14252	NCBI Gene Model \| MGI Sequence Detail	22504	C57BL/6J	± kb
transcript	NM_001431073	RefSeq \| MGI Sequence Detail	2832	C57BL/6
polypeptide	Q60634	UniProt \| EBI \| MGI Sequence Detail	428	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007559 flotillin-2

(term hierarchy)
PDB

1WIN
InterPro Domains

IPR001107 Band 7 domain

IPR036013 Band 7/SPFH domain superfamily

IPR031905 Flotillin, C-terminal domain

IPR027705 Flotillin family
GlyGen

Q60634 1 site, 1 O-linked glycan (1 site)

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All nucleic 109

cDNA 107

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-24193, MGI:2144228

Summaries

All 75

Developmental Gene Expression 3

Gene Ontology 17

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Flot2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103216	Chr11:77928736-77928748 (+)	-15 bp
Tssr103217	Chr11:77928761-77928781 (+)	14 bp
Tssr103218	Chr11:77928785-77928868 (+)	70 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24