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Kpna2 Gene Detail
Summary
  • Symbol
    Kpna2
  • Name
    karyopherin subunit alpha 2
  • Synonyms
    2410044B12Rik, Importin alpha, importin alpha 1, m-importin, m-importin-alpha-P1, pendulin, Rch1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103561
    NCBI Gene: 16647
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106879455-106890351 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103561
 protein coding gene Chr11:106879455-106890367 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019316
 protein coding gene Chr11:110336239-110351582 (-)
A/J MGP_AJ_G0019284
 protein coding gene Chr11:105620089-105633102 (-)
AKR/J MGP_AKRJ_G0019253
 protein coding gene Chr11:108763592-108775364 (-)
BALB/cJ MGP_BALBcJ_G0019258
 protein coding gene Chr11:106032592-106045239 (-)
C3H/HeJ MGP_C3HHeJ_G0019067
 protein coding gene Chr11:109063687-109074762 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019708
 protein coding gene Chr11:113746938-113763712 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017332
 protein coding gene Chr11:102889255-102900278 (-)
CAST/EiJ MGP_CASTEiJ_G0018620
 protein coding gene Chr11:110160870-110172377 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0019148
 protein coding gene Chr11:105094034-105109014 (-)
FVB/NJ MGP_FVBNJ_G0019139
 protein coding gene Chr11:104600981-104612169 (-)
LP/J MGP_LPJ_G0019218
 protein coding gene Chr11:110794425-110802628 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019169
 protein coding gene Chr11:117677798-117691269 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019745
 protein coding gene Chr11:109286320-109301627 (-)
PWK/PhJ MGP_PWKPhJ_G0018385
 protein coding gene Chr11:106208397-106220154 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018176
 protein coding gene Chr11:109059595-109077033 (-)
WSB/EiJ MGP_WSBEiJ_G0018671
 protein coding gene Chr11:109257686-109270605 (-)



Homology
more
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPNA2, karyopherin subunit alpha 2
  • Synonyms
    IPOA1, PTAC58, QIP2, RCH1, SRP1-alpha, SRP1alpha
  • Links
    NCBI Gene ID: 3838
    neXtProt AC: NX_P52292
    UniProt: P52292

  • Chr Location
    17q24.2; chr17:68035636-68047364 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility, with reduced sperm motility and increased sperm abnormalities. Partial prenatal lethality is seen and males and females are smaller.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    971
  • Tissues
    225
  • cDNA Data
    24
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16647 NCBI Gene Model | MGI Sequence Detail 10897 C57BL/6J ±  kb
    transcript NM_010655 RefSeq | MGI Sequence Detail 2071 Not Specified  
    polypeptide P52293 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 25
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24446, MGI:1913724
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 14
      Gene Ontology 22
      Phenotypes 15
    • Earliest
      J:28145 Imamoto N, et al., In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import. EMBO J. 1995 Aug 1;14(15):3617-26
    • Latest
      J:357416 Rother F, et al., Normal male fertility in a mouse model of KPNA2 deficiency. PLoS One. 2024;19(10):e0304189
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory