Cebpe MGI Mouse Gene Detail - MGI:103572 - CCAAT/enhancer binding protein epsilon

Symbol

Cebpe
Name

CCAAT/enhancer binding protein epsilon
Synonyms

C/EBPe, C/EBPepsilon, CRP1, LOC239097

Feature Type

protein coding gene
IDs

MGI:103572
NCBI Gene: 110794
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr14:54947823-54949604 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 27.90 cM
Mapping Data

2 experiments

SNPs within 2kb

130 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103572	protein coding gene	Chr14:54947817-54949631 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021323	protein coding gene	Chr14:48681114-48682922 (-)
A/J	MGP_AJ_G0021282	protein coding gene	Chr14:47722393-47724201 (-)
AKR/J	MGP_AKRJ_G0021258	protein coding gene	Chr14:49446604-49448412 (-)
BALB/cJ	MGP_BALBcJ_G0021286	protein coding gene	Chr14:47697357-47699165 (-)
C3H/HeJ	MGP_C3HHeJ_G0021066	protein coding gene	Chr14:49145751-49147559 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021724	protein coding gene	Chr14:51142504-51144315 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019269	protein coding gene	Chr14:46136984-46138797 (-)
CAST/EiJ	MGP_CASTEiJ_G0020585	protein coding gene	Chr14:45386709-45388517 (-)
CBA/J	MGP_CBAJ_G0021033	protein coding gene	Chr14:52681349-52683157 (-)
DBA/2J	MGP_DBA2J_G0021154	protein coding gene	Chr14:47461602-47463410 (-)
FVB/NJ	MGP_FVBNJ_G0021136	protein coding gene	Chr14:46916194-46918002 (-)
LP/J	MGP_LPJ_G0021228	protein coding gene	Chr14:49679833-49681641 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021160	protein coding gene	Chr14:52075575-52077383 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021751	protein coding gene	Chr14:48636612-48638420 (-)
PWK/PhJ	MGP_PWKPhJ_G0020331	protein coding gene	Chr14:43995509-43997317 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020159	protein coding gene	Chr14:44618450-44620223 (-)
WSB/EiJ	MGP_WSBEiJ_G0020638	protein coding gene	Chr14:48922344-48924152 (-)

Human Ortholog

CEBPE, CCAAT enhancer binding protein epsilon

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEBPE, CCAAT enhancer binding protein epsilon
Synonyms

c/EBP epsilon, C/EBP-epsilon, CRP1, IMD108, SGD1
Links

HGNC:1836

NCBI Gene ID: 1053

neXtProt AC: NX_Q15744

UniProt: Q15744
Chr Location

14q11.2; chr14:23117036-23120256 (-) GRCh38

MGI Vertebrate Homology

Cebpe stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEBPE
Protein SuperFamily

CCAAT/enhancer-binding
Gene Tree

Cebpe

Diseases

1 with human CEBPE associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

27 phenotypes from 1 allele in 2 genetic backgrounds
1 images
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

1 involving Cebpe
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in impaired neutrophil and eosinophil development and myelodysplasia. Mutant animals are susceptible to secondary bacterial infections such as conjuntivitis, rhinitis, and pneumonia, and become moribund between 2-5 months of age.

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All GO Annotations

31
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

12
cDNA Data

10
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cebpe

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All Sequences

31
RefSeq

2
UniProt

3
CCDS

CCDS27100.1

Ensembl

ENSMUSG00000052435 (Evidence)
NCBI Gene

110794

			Length	Strain/Species	Flank
genomic	110794	NCBI Gene Model \| MGI Sequence Detail	1782	C57BL/6J	± kb
transcript	NM_207131	RefSeq \| MGI Sequence Detail	1208	ZRU/MplStud
polypeptide	Q6PZD9	UniProt \| EBI \| MGI Sequence Detail	281	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005310 CCAAT/enhancer-binding protein epsilon

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR031106 CCAAT/enhancer-binding protein C/EBP

IPR016468 CCAAT/enhancer-binding protein, chordates

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All nucleic 16

Genomic 3

cDNA 11

Primer pair 1

Other 1

Microarray probesets 1

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MGD-MRK-24457, MGI:2685140

Summaries

All 61

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 26
Earliest

J:28024 Jenkins NA, et al., Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Genomics. 1995 Jul 20;28(2):333-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cebpe:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128626	Chr14:54949854-54949865 (-)	-256 bp
Tssr128625	Chr14:54949787-54949824 (-)	-202 bp
Tssr128624	Chr14:54949596-54949610 (-)	1 bp
Tssr128623	Chr14:54949577-54949591 (-)	20 bp
Tssr4414	Chr14:54949360-54949406 (-)	221 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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