Ccl11 MGI Mouse Gene Detail - MGI:103576 - C-C motif chemokine ligand 11

Symbol

Ccl11
Name

C-C motif chemokine ligand 11
Synonyms

eotaxin, Scya11

Feature Type

protein coding gene
IDs

MGI:103576
NCBI Gene: 20292
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:81948658-81953781 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 49.84 cM
Mapping Data

12 experiments

SNPs within 2kb

212 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103576	protein coding gene	Chr11:81948649-81953781 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018823	protein coding gene	Chr11:83301856-83309730 (+)
A/J	MGP_AJ_G0018790	protein coding gene	Chr11:80100777-80105853 (+)
AKR/J	MGP_AKRJ_G0018760	protein coding gene	Chr11:82492821-82498882 (+)
BALB/cJ	MGP_BALBcJ_G0018763	protein coding gene	Chr11:80494631-80499691 (+)
C3H/HeJ	MGP_C3HHeJ_G0018577	protein coding gene	Chr11:82544845-82549917 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019215	protein coding gene	Chr11:85800043-85807786 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016849	protein coding gene	Chr11:77071924-77077067 (+)
CAST/EiJ	MGP_CASTEiJ_G0018132	protein coding gene	Chr11:83095360-83100446 (+)
CBA/J	MGP_CBAJ_G0018548	protein coding gene	Chr11:89564836-89569902 (+)
DBA/2J	MGP_DBA2J_G0018656	protein coding gene	Chr11:79661829-79666943 (+)
FVB/NJ	MGP_FVBNJ_G0018645	protein coding gene	Chr11:79209416-79214476 (+)
LP/J	MGP_LPJ_G0018726	protein coding gene	Chr11:83826168-83831092 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018672	protein coding gene	Chr11:89742760-89747818 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019255	protein coding gene	Chr11:82762541-82767607 (+)
PWK/PhJ	MGP_PWKPhJ_G0017902	protein coding gene	Chr11:80488079-80493391 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017693	protein coding gene	Chr11:82374848-82381535 (+)
WSB/EiJ	MGP_WSBEiJ_G0018184	protein coding gene	Chr11:82636653-82643293 (+)

Human Ortholog

CCL11, C-C motif chemokine ligand 11

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL11, C-C motif chemokine ligand 11
Synonyms

SCYA11
Links

HGNC:10610

NCBI Gene ID: 6356

neXtProt AC: NX_P51671

UniProt: P51671
Chr Location

17q12; chr17:34285742-34288334 (+) GRCh38

MGI Vertebrate Homology

Ccl11 stringent orthology
1 human;1 mouse;1 rat;6 zebrafish
HCOP

vertebrate homology predictions: CCL11
Gene Tree

Ccl11

Diseases

3 with human CCL11 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693
				hyperglycemia IDs hyperglycemia DOID:4195 ICD10CM:R73.9 MESH:D006943 NCI:C26797 UMLS_CUI:C0020456

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

2 involving Ccl11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for a disruption in this gene display decreased numbers of eosinophils and impaired eosinophil recruitment after antigen challenge. However, a different homozygous disruption does not result in eosinophil abnormalities.

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All GO Annotations

51
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

9
cDNA Data

16
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

2
UniProt

1
CCDS

CCDS36246.1

Ensembl

ENSMUSG00000020676 (Evidence)
NCBI Gene

20292

			Length	Strain/Species	Flank
genomic	20292	NCBI Gene Model \| MGI Sequence Detail	5124	C57BL/6J	± kb
transcript	NM_011330	RefSeq \| MGI Sequence Detail	1073	ZRU/MplStud
polypeptide	P48298	UniProt \| EBI \| MGI Sequence Detail	97	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000002139 eotaxin

(term hierarchy)
InterPro Domains

IPR000827 CC chemokine, conserved site

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily
GlyGen

P48298 1 site

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All nucleic 23

Genomic 2

cDNA 18

Primer pair 3

Microarray probesets 2

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MGD-MRK-24461

Summaries

All 105

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 45
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:317198 Yang Y, et al., Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation. Nat Commun. 2021 Dec 10;12(1):7186

TSS for Ccl11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103565	Chr11:81948671-81948682 (+)	19 bp
Tssr103566	Chr11:81948711-81948714 (+)	55 bp
Tssr103567	Chr11:81948740-81948755 (+)	90 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24