Madcam1 MGI Mouse Gene Detail - MGI:103579 - mucosal vascular addressin cell adhesion molecule 1

Symbol

Madcam1
Name

mucosal vascular addressin cell adhesion molecule 1
Synonyms

MGC:35998

Feature Type

protein coding gene
IDs

MGI:103579
NCBI Gene: 17123
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:79500393-79504371 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1-C2
Mapping Data

6 experiments

SNPs within 2kb

124 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103579	protein coding gene	Chr10:79500393-79504376 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017450	protein coding gene	Chr10:80201100-80205062 (+)
A/J	MGP_AJ_G0017428	protein coding gene	Chr10:77414571-77418533 (+)
AKR/J	MGP_AKRJ_G0017389	protein coding gene	Chr10:79520268-79524228 (+)
BALB/cJ	MGP_BALBcJ_G0017390	protein coding gene	Chr10:77643438-77647400 (+)
C3H/HeJ	MGP_C3HHeJ_G0017213	protein coding gene	Chr10:79626252-79630214 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017844	protein coding gene	Chr10:82973893-82977855 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015532	protein coding gene	Chr10:73642317-73646379 (+)
CAST/EiJ	MGP_CASTEiJ_G0016780	protein coding gene	Chr10:79801054-79804993 (+)
CBA/J	MGP_CBAJ_G0017185	protein coding gene	Chr10:86200694-86204656 (+)
DBA/2J	MGP_DBA2J_G0017291	protein coding gene	Chr10:76632969-76636931 (+)
FVB/NJ	MGP_FVBNJ_G0017285	protein coding gene	Chr10:75793344-75797306 (+)
LP/J	MGP_LPJ_G0017362	protein coding gene	Chr10:80680883-80684845 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017311	protein coding gene	Chr10:88178473-88182435 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017885	protein coding gene	Chr10:79499630-79503592 (+)
PWK/PhJ	MGP_PWKPhJ_G0016561	protein coding gene	Chr10:76490213-76494297 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016350	protein coding gene	Chr10:78474763-78478800 (+)
WSB/EiJ	MGP_WSBEiJ_G0016840	protein coding gene	Chr10:79527597-79531559 (+)

Human Ortholog

MADCAM1, mucosal vascular addressin cell adhesion molecule 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MADCAM1, mucosal vascular addressin cell adhesion molecule 1
Synonyms

MACAM1
Links

HGNC:6765

NCBI Gene ID: 8174

neXtProt AC: NX_Q13477

UniProt: Q13477
Chr Location

19p13.3; chr19:489176-505343 (+) GRCh38

MGI Vertebrate Homology

Madcam1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MADCAM1
Gene Tree

Madcam1

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

10
Targeted

6
Genomic Mutations

1 involving Madcam1
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit small Peyer's patches and decreased homing of IgA-secreting plasma cells in the lamina propria.

less

All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

16
cDNA Data

18
Literature Summary

31

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase madcam1

less

All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS23981.1, CCDS88048.1

Ensembl

ENSMUSG00000020310 (Evidence)
NCBI Gene

17123

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020310	Ensembl Gene Model \| MGI Sequence Detail	3979	C57BL/6J	± kb
transcript	ENSMUST00000020554	Ensembl \| MGI Sequence Detail	1436	Not Applicable
polypeptide	ENSMUSP00000020554	Ensembl \| MGI Sequence Detail	405	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000010041 mucosal addressin cell adhesion molecule 1

(term hierarchy)
InterPro Domains

IPR015169 Adhesion molecule, immunoglobulin-like

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR037413 Mucosal addressin cell adhesion molecule 1
GlyGen

Q61826 3 sites

less

All nucleic 24

Genomic 4

cDNA 18

Primer pair 2

Microarray probesets 2

less

MGD-MRK-24464, MGI:2143785

Summaries

All 101

Developmental Gene Expression 31

Gene Ontology 8

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:343753 He C, et al., Gut-licensed beta7(+) CD4(+) T cells contribute to progressive retinal ganglion cell damage in glaucoma. Sci Transl Med. 2023 Aug 2;15(707):eadg1656

TSS for Madcam1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3268	Chr10:79500208-79500217 (+)	-180 bp
Tssr94357	Chr10:79500387-79500398 (+)	0 bp
Tssr94358	Chr10:79500421-79500437 (+)	36 bp
Tssr94359	Chr10:79501301-79501304 (+)	910 bp
Tssr94360	Chr10:79501334-79501344 (+)	946 bp
Tssr94361	Chr10:79501364-79501368 (+)	973 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24