Slc23a3 MGI Mouse Gene Detail - MGI:104516 - solute carrier family 23 (nucleobase transporters), member 3

Symbol

Slc23a3
Name

solute carrier family 23 (nucleobase transporters), member 3
Synonyms

SVCT3, Yspl1

Feature Type

protein coding gene
IDs

MGI:104516
NCBI Gene: 22626
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:75102185-75110534 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.60 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

267 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104516	protein coding gene	Chr1:75102185-75112113 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016170	protein coding gene	Chr1:75684125-75692474 (-)
A/J	MGP_AJ_G0016153	protein coding gene	Chr1:73046342-73054696 (-)
AKR/J	MGP_AKRJ_G0016110	protein coding gene	Chr1:75074819-75083172 (-)
BALB/cJ	MGP_BALBcJ_G0016108	protein coding gene	Chr1:73109559-73117908 (-)
C3H/HeJ	MGP_C3HHeJ_G0015939	protein coding gene	Chr1:75406141-75414495 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016561	protein coding gene	Chr1:78638332-78646681 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014282	protein coding gene	Chr1:68608632-68617518 (-)
CAST/EiJ	MGP_CASTEiJ_G0015523	protein coding gene	Chr1:74740860-74751143 (-)
CBA/J	MGP_CBAJ_G0015912	protein coding gene	Chr1:81191871-81200225 (-)
DBA/2J	MGP_DBA2J_G0016013	protein coding gene	Chr1:72366212-72374561 (-)
FVB/NJ	MGP_FVBNJ_G0016016	protein coding gene	Chr1:71562608-71570990 (-)
LP/J	MGP_LPJ_G0016085	protein coding gene	Chr1:76810289-76818638 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016036	protein coding gene	Chr1:84552997-84561351 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016608	protein coding gene	Chr1:75143209-75151558 (-)
PWK/PhJ	MGP_PWKPhJ_G0015310	protein coding gene	Chr1:71833883-71842550 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015088	protein coding gene	Chr1:74505734-74514160 (-)
WSB/EiJ	MGP_WSBEiJ_G0015585	protein coding gene	Chr1:74956630-74964982 (-)

Human Ortholog

SLC23A3, solute carrier family 23 member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC23A3, solute carrier family 23 member 3
Synonyms

E2BP3, SVCT3, Yspl1
Links

HGNC:20601

NCBI Gene ID: 151295

neXtProt AC: NX_Q6PIS1

UniProt: Q6PIS1
Chr Location

2q35; chr2:219161465-219170095 (-) GRCh38

MGI Vertebrate Homology

Slc23a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC23A3
Gene Tree

Slc23a3

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Spontaneous

1
Genomic Mutations

4 involving Slc23a3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

762
Tissues

53
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc23a3

ZFIN slc23a3

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All Sequences

46
RefSeq

13
UniProt

2
CCDS

CCDS15062.1

Ensembl

ENSMUSG00000026205 (Evidence)
NCBI Gene

22626

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026205	Ensembl Gene Model \| MGI Sequence Detail	8350	C57BL/6J	± kb
transcript	ENSMUST00000027405	Ensembl \| MGI Sequence Detail	2059	Not Applicable
polypeptide	ENSMUSP00000027405	Ensembl \| MGI Sequence Detail	611	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030434 solute carrier family 23 member 3

(term hierarchy)
InterPro Domains

IPR006043 Nucleobase cation symporter 2 family

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All nucleic 20

Genomic 1

cDNA 17

Primer pair 2

Microarray probesets 5

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MGD-MRK-25947

Summaries

All 50

Developmental Gene Expression 3

Diseases 1

Gene Ontology 4

Phenotypes 24
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc23a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12346	Chr1:75110537-75110557 (-)	-13 bp
Tssr12345	Chr1:75110510-75110532 (-)	13 bp
Tssr12344	Chr1:75110217-75110222 (-)	314 bp
Tssr12343	Chr1:75110173-75110203 (-)	346 bp
Tssr12342	Chr1:75110151-75110160 (-)	378 bp
Tssr12341	Chr1:75110122-75110127 (-)	409 bp
Tssr12340	Chr1:75105287-75105299 (-)	5,241 bp
Tssr12339	Chr1:75105245-75105265 (-)	5,279 bp
Tssr12338	Chr1:75105221-75105244 (-)	5,301 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24