Apof MGI Mouse Gene Detail - MGI:104539

Symbol

Apof
Name

apolipoprotein F

Feature Type

protein coding gene
IDs

MGI:104539
NCBI Gene: 103161
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:128103866-128106022 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.50 cM
Mapping Data

8 experiments

SNPs within 2kb

168 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104539	protein coding gene	Chr10:128103866-128107119 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017855	protein coding gene	Chr10:131983343-131985497 (+)
A/J	MGP_AJ_G0017830	protein coding gene	Chr10:126689872-126692025 (+)
AKR/J	MGP_AKRJ_G0017793	protein coding gene	Chr10:130414437-130416591 (+)
BALB/cJ	MGP_BALBcJ_G0017794	protein coding gene	Chr10:127073089-127075243 (+)
C3H/HeJ	MGP_C3HHeJ_G0017617	protein coding gene	Chr10:130563496-130565650 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018249	protein coding gene	Chr10:136458986-136461140 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015927	protein coding gene	Chr10:120626037-120628202 (+)
CAST/EiJ	MGP_CASTEiJ_G0017178	protein coding gene	Chr10:131282674-131284838 (+)
CBA/J	MGP_CBAJ_G0017587	protein coding gene	Chr10:141995201-141997355 (+)
DBA/2J	MGP_DBA2J_G0017693	protein coding gene	Chr10:125753068-125755222 (+)
FVB/NJ	MGP_FVBNJ_G0017688	protein coding gene	Chr10:124681699-124683853 (+)
LP/J	MGP_LPJ_G0017767	protein coding gene	Chr10:132580709-132582863 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017716	protein coding gene	Chr10:144596111-144598265 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018289	protein coding gene	Chr10:130507093-130509247 (+)
PWK/PhJ	MGP_PWKPhJ_G0016963	protein coding gene	Chr10:126011016-126013177 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016752	protein coding gene	Chr10:129597327-129599490 (+)
WSB/EiJ	MGP_WSBEiJ_G0017237	protein coding gene	Chr10:130725886-130728040 (+)

Human Ortholog

APOF, apolipoprotein F

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOF, apolipoprotein F
Synonyms

Apo-F, LTIP
Links

HGNC:615

NCBI Gene ID: 319

neXtProt AC: NX_Q13790

UniProt: Q13790
Chr Location

12q13.3; chr12:56360568-56362857 (-) GRCh38

MGI Vertebrate Homology

Apof stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: APOF
Gene Tree

Apof

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired ABCG1-mediated cholesterol efflux.

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All GO Annotations

9
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

787
Tissues

21
cDNA Data

60
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN apof

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS24268.2

Ensembl

ENSMUSG00000047631 (Evidence)
NCBI Gene

103161

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047631	Ensembl Gene Model \| MGI Sequence Detail	2157	C57BL/6J	± kb
transcript	ENSMUST00000238970	Ensembl \| MGI Sequence Detail	1930	Not Applicable
polypeptide	ENSMUSP00000158988	Ensembl \| MGI Sequence Detail	326	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004156 apolipoprotein F

(term hierarchy)
InterPro Domains

IPR026114 Apolipoprotein F

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All nucleic 60

cDNA 60

Microarray probesets 3

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MGD-MRK-25971, MGI:2143547

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 9
Earliest

J:34160 Gwynn B, et al., Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. Genomics. 1996 Jul 15;35(2):389-91
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Apof:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96374	Chr10:128104493-128104508 (+)	635 bp
Tssr96375	Chr10:128104515-128104520 (+)	652 bp
Tssr96376	Chr10:128104525-128104591 (+)	692 bp
Tssr96377	Chr10:128104719-128104738 (+)	863 bp
Tssr96378	Chr10:128105042-128105063 (+)	1,187 bp
Tssr96379	Chr10:128105070-128105082 (+)	1,210 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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