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Clec3b Gene Detail
Summary
  • Symbol
    Clec3b
  • Name
    C-type lectin domain family 3, member b
  • Synonyms
    Tna
  • Feature Type
    protein coding gene
  • IDs
    MGI:104540
    NCBI Gene: 21922
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:122980011-122986497 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 73.91 cM, cytoband F1-F3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    318 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104540
 protein coding gene Chr9:122980011-122986497 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035473
 protein coding gene Chr9:126172728-126183553 (+)
A/J MGP_AJ_G0035454
 protein coding gene Chr9:121344953-121351839 (+)
AKR/J MGP_AKRJ_G0035387
 protein coding gene Chr9:124606824-124616931 (+)
BALB/cJ MGP_BALBcJ_G0035450
 protein coding gene Chr9:121274964-121281723 (+)
C3H/HeJ MGP_C3HHeJ_G0035157
 protein coding gene Chr9:125052535-125060206 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035973
 protein coding gene Chr9:129666996-129673461 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032855
 protein coding gene Chr9:118490144-118496746 (+)
CAST/EiJ MGP_CASTEiJ_G0034462
 protein coding gene Chr9:125082398-125090139 (+)
CBA/J MGP_CBAJ_G0035125
 protein coding gene Chr9:134372153-134378618 (+)
DBA/2J MGP_DBA2J_G0035284
 protein coding gene Chr9:120798922-120806798 (+)
FVB/NJ MGP_FVBNJ_G0035231
 protein coding gene Chr9:119705864-119712727 (+)
LP/J MGP_LPJ_G0035363
 protein coding gene Chr9:126510246-126516948 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035272
 protein coding gene Chr9:135223228-135230176 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035992
 protein coding gene Chr9:125070394-125078121 (+)
PWK/PhJ MGP_PWKPhJ_G0034166
 protein coding gene Chr9:121253972-121260663 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034003
 protein coding gene Chr9:125176108-125182645 (+)
WSB/EiJ MGP_WSBEiJ_G0034582
 protein coding gene Chr9:124917101-124924298 (+)



Homology
more
  • Human Ortholog
    CLEC3B, C-type lectin domain family 3 member B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC3B, C-type lectin domain family 3 member B
  • Synonyms
    MCDR4, TN, TNA
  • Links
    NCBI Gene ID: 7123
    neXtProt AC: NX_P05452
    UniProt: P05452

  • Chr Location
    3p21.31; chr3:45001548-45036071 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Clec3b mouse models; 2 with human CLEC3B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop pronounced cervical lordosis and thoracic kyphosis associated with wedge-shaped deformities of the vertebrae, growth plate irregularities, and an asymmetric development of the intervertebral disks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    34
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21922 NCBI Gene Model | MGI Sequence Detail 6487 C57BL/6J ±  kb
    transcript NM_011606 RefSeq | MGI Sequence Detail 1009 ZRU/MplStud  
    polypeptide P43025 UniProt | EBI | MGI Sequence Detail 202 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-25972
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:190010 Wewer UM, et al., A potential role for tetranectin in mineralization during osteogenesis. J Cell Biol. 1994 Dec;127(6 Pt 1):1767-75
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory