Napb MGI Mouse Gene Detail - MGI:104562 - N-ethylmaleimide sensitive fusion protein attachment protein beta

Symbol

Napb
Name

N-ethylmaleimide sensitive fusion protein attachment protein beta
Synonyms

Brp14, b-SNAP, E161, I47, SNARE

Feature Type

protein coding gene
IDs

MGI:104562
NCBI Gene: 17957
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:148535905-148574387 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 73.53 cM
Mapping Data

2 experiments

SNPs within 2kb

1354 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104562	protein coding gene	Chr2:148535905-148574396 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026611	protein coding gene	Chr2:153042136-153084126 (-)
A/J	MGP_AJ_G0026575	protein coding gene	Chr2:146819648-146857877 (-)
AKR/J	MGP_AKRJ_G0026549	protein coding gene	Chr2:151058354-151096559 (-)
BALB/cJ	MGP_BALBcJ_G0026587	protein coding gene	Chr2:147249690-147288335 (-)
C3H/HeJ	MGP_C3HHeJ_G0026330	protein coding gene	Chr2:151560110-151599941 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027032	protein coding gene	Chr2:157507174-157545133 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024410	protein coding gene	Chr2:140819707-140860758 (-)
CAST/EiJ	MGP_CASTEiJ_G0025791	protein coding gene	Chr2:151950433-151992042 (-)
CBA/J	MGP_CBAJ_G0026310	protein coding gene	Chr2:163283267-163321405 (-)
DBA/2J	MGP_DBA2J_G0026444	protein coding gene	Chr2:146086982-146125853 (-)
FVB/NJ	MGP_FVBNJ_G0026408	protein coding gene	Chr2:144581475-144619658 (-)
LP/J	MGP_LPJ_G0026548	protein coding gene	Chr2:153177181-153219224 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026428	protein coding gene	Chr2:167321031-167363748 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027087	protein coding gene	Chr2:151068627-151107509 (-)
PWK/PhJ	MGP_PWKPhJ_G0025527	protein coding gene	Chr2:145760544-145799034 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025328	protein coding gene	Chr2:150033591-150074330 (-)
WSB/EiJ	MGP_WSBEiJ_G0025865	protein coding gene	Chr2:152008022-152048269 (-)

Human Ortholog

NAPB, NSF attachment protein beta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAPB, NSF attachment protein beta
Synonyms

DEE107, SNAPB, SNAP-BETA
Links

HGNC:15751

NCBI Gene ID: 63908

neXtProt AC: NX_Q9H115

UniProt: Q9H115
Chr Location

20p11.21; chr20:23374519-23421519 (-) GRCh38

MGI Vertebrate Homology

Napb stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: NAPB
Gene Tree

Napb

Diseases

1 with human NAPB associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 107 IDs developmental and epileptic encephalopathy 107 DOID:0070393 OMIM:620033

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Napb
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for a knock-out allele exhibit seizures, ataxia, abnormal synaptic vesicle priming, and premature death.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

46
cDNA Data

8
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase napb

ZFIN napba, napbb

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All Sequences

45
RefSeq

5
UniProt

3
CCDS

CCDS16842.1

Ensembl

ENSMUSG00000027438 (Evidence)
NCBI Gene

17957

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027438	Ensembl Gene Model \| MGI Sequence Detail	38483	C57BL/6J	± kb
transcript	ENSMUST00000028926	Ensembl \| MGI Sequence Detail	4412	Not Applicable
polypeptide	ENSMUSP00000028926	Ensembl \| MGI Sequence Detail	298	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010982 beta-soluble NSF attachment protein

(term hierarchy)
InterPro Domains

IPR000744 NSF attachment protein

IPR011990 Tetratricopeptide-like helical domain superfamily
GlyGen

P28663 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 9

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MGD-MRK-25996, MGI:1930655

Summaries

All 47

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Napb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26672	Chr2:148574377-148574383 (-)	7 bp
Tssr26671	Chr2:148574298-148574375 (-)	50 bp
Tssr26670	Chr2:148574288-148574292 (-)	97 bp
Tssr26669	Chr2:148543125-148543136 (-)	31,256 bp
Tssr26668	Chr2:148543092-148543103 (-)	31,289 bp
Tssr26667	Chr2:148538916-148538927 (-)	35,465 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24