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Napa Gene Detail
Summary
  • Symbol
    Napa
  • Name
    N-ethylmaleimide sensitive fusion protein attachment protein alpha
  • Synonyms
    1500039N14Rik, a-SNAP, hyh, RA81, SNAPA, SNARE
  • Feature Type
    protein coding gene
  • IDs
    MGI:104563
    NCBI Gene: 108124
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15832383-15851900 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.74 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104563
 protein coding gene Chr7:15832127-15851907 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031698
 protein coding gene Chr7:13752821-13773495 (+)
A/J MGP_AJ_G0031670
 protein coding gene Chr7:13558613-13578134 (+)
AKR/J MGP_AKRJ_G0031595
 protein coding gene Chr7:13861273-13880798 (+)
BALB/cJ MGP_BALBcJ_G0031677
 protein coding gene Chr7:13658418-13677931 (+)
C3H/HeJ MGP_C3HHeJ_G0031399
 protein coding gene Chr7:14034587-14054133 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032143
 protein coding gene Chr7:14510140-14529630 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029222
 protein coding gene Chr7:15116233-15135925 (+)
CAST/EiJ MGP_CASTEiJ_G0030750
 protein coding gene Chr7:10804637-10824125 (+)
CBA/J MGP_CBAJ_G0031358
 protein coding gene Chr7:14952172-14975009 (+)
DBA/2J MGP_DBA2J_G0031514
 protein coding gene Chr7:13445404-13464790 (+)
FVB/NJ MGP_FVBNJ_G0031470
 protein coding gene Chr7:13330073-13349623 (+)
LP/J MGP_LPJ_G0031599
 protein coding gene Chr7:14026090-14045623 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031505
 protein coding gene Chr7:14934202-14954900 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032172
 protein coding gene Chr7:13633945-13654612 (+)
PWK/PhJ MGP_PWKPhJ_G0030474
 protein coding gene Chr7:10953439-10972923 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030302
 protein coding gene Chr7:8566212-8585710 (+)
WSB/EiJ MGP_WSBEiJ_G0030847
 protein coding gene Chr7:13673089-13692656 (+)



Homology
more
  • Human Ortholog
    NAPA, NSF attachment protein alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAPA, NSF attachment protein alpha
  • Synonyms
    SNAPA
  • Links
    NCBI Gene ID: 8775
    neXtProt AC: NX_P54920
    UniProt: P54920

  • Chr Location
    19q13.32-q13.33; chr19:47484530-47515091 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The homozygous null mutation is embryonic lethal while partial loss of function homozygous mutants develop hydrocephalus and die postnatally. These mutants also display central nervous system abnormalities and impaired motor capabilities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    41
  • cDNA Data
    239
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006024 Ensembl Gene Model | MGI Sequence Detail 19518 C57BL/6J ±  kb
    transcript ENSMUST00000006181 Ensembl | MGI Sequence Detail 2517 Not Applicable  
    polypeptide ENSMUSP00000006181 Ensembl | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 240
      cDNA 240

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11037, MGD-MRK-25997, MGI:1328319, MGI:1914252, MGI:2142218, MGI:96302
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:12732 Bronson RT, et al., Hydrocephalus with hop gait (hyh): a new mutation on chromosome 7 in the mouse. Brain Res Dev Brain Res. 1990 Jun 1;54(1):131-6
    • Latest
      J:345833 Rodriguez-Perez LM, et al., A selective defect in the glial wedge as part of the neuroepithelium disruption in hydrocephalus development in the mouse hyh model is associated with complete corpus callosum dysgenesis. Front Cell Neurosci. 2024;18:1330412
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory