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Eps15 Gene Detail
Summary
  • Symbol
    Eps15
  • Name
    epidermal growth factor receptor pathway substrate 15
  • Synonyms
    2410112D09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:104583
    NCBI Gene: 13858
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:109137465-109245014 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 51.29 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1870 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104583
 protein coding gene Chr4:109137372-109245014 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028569
 protein coding gene Chr4:110062105-110164232 (+)
A/J MGP_AJ_G0028532
 protein coding gene Chr4:106096457-106195178 (+)
AKR/J MGP_AKRJ_G0028479
 protein coding gene Chr4:108733768-108839883 (+)
BALB/cJ MGP_BALBcJ_G0028551
 protein coding gene Chr4:106307996-106409431 (+)
C3H/HeJ MGP_C3HHeJ_G0028265
 protein coding gene Chr4:109484632-109585678 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028991
 protein coding gene Chr4:114015559-114120233 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026282
 protein coding gene Chr4:101390122-101490122 (+)
CAST/EiJ MGP_CASTEiJ_G0027701
 protein coding gene Chr4:107331444-107437083 (+)
CBA/J MGP_CBAJ_G0028234
 protein coding gene Chr4:117768089-117870687 (+)
DBA/2J MGP_DBA2J_G0028382
 protein coding gene Chr4:105717285-105816272 (+)
FVB/NJ MGP_FVBNJ_G0028350
 protein coding gene Chr4:104595069-104692396 (+)
LP/J MGP_LPJ_G0028483
 protein coding gene Chr4:110303185-110408202 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028376
 protein coding gene Chr4:122943996-123050155 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029027
 protein coding gene Chr4:108977374-109081994 (+)
PWK/PhJ MGP_PWKPhJ_G0027427
 protein coding gene Chr4:104003662-104105994 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027251
 protein coding gene Chr4:106356772-106460380 (+)
WSB/EiJ MGP_WSBEiJ_G0027782
 protein coding gene Chr4:109162560-109262231 (+)



Homology
more
  • Human Ortholog
    EPS15, epidermal growth factor receptor pathway substrate 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPS15, epidermal growth factor receptor pathway substrate 15
  • Synonyms
    AF-1P, AF1P, MLLT5
  • Links
    NCBI Gene ID: 2060
    neXtProt AC: NX_P42566
    UniProt: P42566

  • Chr Location
    1p32.3; chr1:51354263-51519328 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    25 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased marginal zone B cell number with no changes in precursor cells, proliferation, apoptosis, migration or B cell responses. Homozygotes for a different null allele show decreased mean corpuscular hemoglobin (MCH), decreased MCH concentration, and dermatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    941
  • Tissues
    88
  • cDNA Data
    124
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028552 Ensembl Gene Model | MGI Sequence Detail 107550 C57BL/6J ±  kb
    transcript ENSMUST00000175776 Ensembl | MGI Sequence Detail 2802 Not Applicable  
    polypeptide ENSMUSP00000135270 Ensembl | MGI Sequence Detail 933 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 125

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26017, MGI:1920919
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 18
      Phenotypes 21
    • Earliest
      J:29845 Fazioli F, et al., eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol Cell Biol. 1993 Sep;13(9):5814-28
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory