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Nbl1 Gene Detail
Summary
  • Symbol
    Nbl1
  • Name
    NBL1, DAN family BMP antagonist
  • Synonyms
    D4H1S1733E, DAN, Dana, NO3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104591
    NCBI Gene: 17965
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138809595-138820304 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.57 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    316 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104591
 protein coding gene Chr4:138809595-138820437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029011
 protein coding gene Chr4:141891483-141903884 (-)
A/J MGP_AJ_G0028970
 protein coding gene Chr4:135793770-135804516 (-)
AKR/J MGP_AKRJ_G0028922
 protein coding gene Chr4:139683739-139695751 (-)
BALB/cJ MGP_BALBcJ_G0028994
 protein coding gene Chr4:136473616-136484280 (-)
C3H/HeJ MGP_C3HHeJ_G0028708
 protein coding gene Chr4:140063317-140073936 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029435
 protein coding gene Chr4:146915126-146927192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026706
 protein coding gene Chr4:128765284-128776159 (-)
CAST/EiJ MGP_CASTEiJ_G0028140
 protein coding gene Chr4:138248216-138258843 (-)
CBA/J MGP_CBAJ_G0028672
 protein coding gene Chr4:151150446-151167580 (-)
DBA/2J MGP_DBA2J_G0028822
 protein coding gene Chr4:136178253-136190367 (-)
FVB/NJ MGP_FVBNJ_G0028789
 protein coding gene Chr4:135212999-135224407 (-)
LP/J MGP_LPJ_G0028921
 protein coding gene Chr4:141972735-141983372 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028815
 protein coding gene Chr4:155062006-155072647 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029473
 protein coding gene Chr4:140211516-140223110 (-)
PWK/PhJ MGP_PWKPhJ_G0027861
 protein coding gene Chr4:133039239-133050542 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027686
 protein coding gene Chr4:135973575-135987144 (-)
WSB/EiJ MGP_WSBEiJ_G0028218
 protein coding gene Chr4:140460974-140475307 (-)



Homology
more
  • Human Ortholog
    MICOS10-NBL1, MICOS10-NBL1 readthrough
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MICOS10-NBL1, MICOS10-NBL1 readthrough
  • Synonyms
    C1orf151-NBL1, DAN, DAND1, MINOS1-NBL1, NBL1
  • Links
    NCBI Gene ID: 100532736
    neXtProt AC: NX_P41271
    UniProt: P41271

  • Chr Location
    1p36.13; chr1:19596979-19658456 (+)  GRCh38
  • Human Ortholog
    NBL1, NBL1, DAN family BMP antagonist
  • Synonyms
    D1S1733E, DAN, DAND1, NB, NO3
  • Links
    NCBI Gene ID: 4681
    neXtProt AC: NX_P41271
    UniProt: P41271

  • Chr Location
    1p36.13; chr1:19596979-19658456 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    3 involving Nbl1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    16 strains or lines available
Mice homozygous for disruptions in this gene appear to have a normal nervous system, although one allele exhibits reduced sensitivity to pain during inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1087
  • Tissues
    113
  • cDNA Data
    78
  • Literature Summary
    22
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041120 Ensembl Gene Model | MGI Sequence Detail 10710 C57BL/6J ±  kb
transcript ENSMUST00000042844 Ensembl | MGI Sequence Detail 1793 Not Applicable  
polypeptide ENSMUSP00000045608 Ensembl | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 82
    cDNA 79
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-26025, MGD-MRK-33709
References
more
  • Summaries
    All 55
    Developmental Gene Expression 22
    Gene Ontology 9
    Phenotypes 9
  • Earliest
    J:31883 Ozaki T, et al., Cloning of mouse DAN cDNA and its down-regulation in transformed cells. Jpn J Cancer Res. 1996 Jan;87(1):58-61
  • Latest
    J:322043 Liu M, et al., Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling. Nat Commun. 2022 Feb 22;13(1):1006
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory