Procr MGI Mouse Gene Detail - MGI:104596 - protein C receptor, endothelial

Symbol

Procr
Name

protein C receptor, endothelial
Synonyms

Ccca, EPCR

Feature Type

protein coding gene
IDs

MGI:104596
NCBI Gene: 19124
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:155593037-155597391 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.26 cM, cytoband H1-3
Mapping Data

2 experiments

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104596	protein coding gene	Chr2:155592159-155597391 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026742	protein coding gene	Chr2:160589400-160593703 (+)
A/J	MGP_AJ_G0026708	protein coding gene	Chr2:154211862-154216260 (+)
AKR/J	MGP_AKRJ_G0026679	protein coding gene	Chr2:158699153-158703507 (+)
BALB/cJ	MGP_BALBcJ_G0026717	protein coding gene	Chr2:154509936-154514285 (+)
C3H/HeJ	MGP_C3HHeJ_G0026460	protein coding gene	Chr2:159046905-159051214 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027166	protein coding gene	Chr2:165297804-165302148 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024536	protein coding gene	Chr2:147704181-147708493 (+)
CAST/EiJ	MGP_CASTEiJ_G0025921	protein coding gene	Chr2:159363248-159367562 (+)
CBA/J	MGP_CBAJ_G0026437	protein coding gene	Chr2:171302279-171306586 (+)
DBA/2J	MGP_DBA2J_G0026574	protein coding gene	Chr2:153394511-153398847 (+)
FVB/NJ	MGP_FVBNJ_G0026541	protein coding gene	Chr2:151769417-151773731 (+)
LP/J	MGP_LPJ_G0026679	protein coding gene	Chr2:160734995-160739295 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026562	protein coding gene	Chr2:175293783-175298092 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027222	protein coding gene	Chr2:158565559-158569868 (+)
PWK/PhJ	MGP_PWKPhJ_G0025655	protein coding gene	Chr2:152891834-152896266 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025458	protein coding gene	Chr2:157506745-157511043 (+)
WSB/EiJ	MGP_WSBEiJ_G0025991	protein coding gene	Chr2:159456775-159461085 (+)

Human Ortholog

PROCR, protein C receptor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PROCR, protein C receptor
Synonyms

CCCA, CCD41, EPCR
Links

HGNC:9452

NCBI Gene ID: 10544

neXtProt AC: NX_Q9UNN8

UniProt: Q9UNN8
Chr Location

20q11.22; chr20:35171096-35216259 (+) GRCh38

MGI Vertebrate Homology

Procr stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PROCR
Gene Tree

Procr

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Phenotype Summary

32 phenotypes from 7 alleles in 11 genetic backgrounds
2 phenotypes from multigenic genotypes
1 images
55 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

8
Gene trapped

2
Targeted

14
Transgenic

1
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Nullizygous embryos die by E10.5 showing placental thrombosis, small size, and incomplete turning. Mice with a severe deficiency survive and reproduce normally. Homozygotes for the R84A variant show increased thrombin formation after thrombotic and LPS challenge, splenomegaly, and bone marrow failure.

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All GO Annotations

13
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

829
Tissues

86
cDNA Data

41
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

8
UniProt

3
CCDS

CCDS16954.1

Ensembl

ENSMUSG00000027611 (Evidence)
NCBI Gene

19124

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027611	Ensembl Gene Model \| MGI Sequence Detail	4355	C57BL/6J	± kb
transcript	ENSMUST00000029140	Ensembl \| MGI Sequence Detail	1597	Not Applicable
polypeptide	ENSMUSP00000029140	Ensembl \| MGI Sequence Detail	242	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001347 endothelial protein C receptor

(term hierarchy)
InterPro Domains

IPR015669 Endothelial protein C receptor

IPR011162 MHC classes I/II-like antigen recognition protein

IPR011161 MHC class I-like antigen recognition-like

IPR037055 MHC class I-like antigen recognition-like superfamily
GlyGen

Q64695 5 sites, 2 N-linked glycans (3 sites)

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All nucleic 43

cDNA 41

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-24087, MGD-MRK-26030, MGI:2138904

Summaries

All 93

Developmental Gene Expression 9

Gene Ontology 10

Phenotypes 55
Earliest

J:22114 Rothbarth K, et al., cDNA-derived molecular characteristics and antibodies to a new centrosome-associated and G2/M phase-prevalent protein. J Cell Sci. 1993 Jan;104(Pt 1):19-30
Latest

J:354658 Chen Q, et al., Heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice. Blood. 2024 Aug 1;144(5):552-564

TSS for Procr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21115	Chr2:155592699-155592714 (+)	-330 bp
Tssr21116	Chr2:155592725-155592739 (+)	-305 bp
Tssr21117	Chr2:155593030-155593040 (+)	-2 bp
Tssr21118	Chr2:155593119-155593204 (+)	125 bp
Tssr21119	Chr2:155593244-155593255 (+)	213 bp
Tssr21120	Chr2:155593260-155593290 (+)	238 bp
Tssr21121	Chr2:155596865-155596877 (+)	3,834 bp
Tssr21122	Chr2:155596904-155596914 (+)	3,872 bp
Tssr21123	Chr2:155596920-155596934 (+)	3,890 bp
Tssr21124	Chr2:155596975-155596988 (+)	3,945 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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