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Tnnt2 Gene Detail
Summary
  • Symbol
    Tnnt2
  • Name
    troponin T2, cardiac
  • Synonyms
    cardiac TnT, cTnT, Tnt
  • Feature Type
    protein coding gene
  • IDs
    MGI:104597
    NCBI Gene: 21956
  • Alliance
    gene page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135764092-135779998 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 59.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    612 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104597
 protein coding gene Chr1:135763933-135780006 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016530
 protein coding gene Chr1:139624009-139639753 (+)
A/J MGP_AJ_G0016513
 protein coding gene Chr1:134340455-134356165 (+)
AKR/J MGP_AKRJ_G0016478
 protein coding gene Chr1:138337919-138353728 (+)
BALB/cJ MGP_BALBcJ_G0016473
 protein coding gene Chr1:134660894-134677142 (+)
C3H/HeJ MGP_C3HHeJ_G0016299
 protein coding gene Chr1:138435568-138452370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016934
 protein coding gene Chr1:144650228-144666073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014645
 protein coding gene Chr1:127445423-127461111 (+)
CAST/EiJ MGP_CASTEiJ_G0015879
 protein coding gene Chr1:137517728-137533638 (+)
CBA/J MGP_CBAJ_G0016272
 protein coding gene Chr1:149655159-149671014 (+)
DBA/2J MGP_DBA2J_G0016378
 protein coding gene Chr1:133335629-133351430 (+)
FVB/NJ MGP_FVBNJ_G0016377
 protein coding gene Chr1:131981666-131997581 (+)
LP/J MGP_LPJ_G0016449
 protein coding gene Chr1:140855403-140871137 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016402
 protein coding gene Chr1:155312491-155328394 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016970
 protein coding gene Chr1:138105356-138123616 (+)
PWK/PhJ MGP_PWKPhJ_G0015665
 protein coding gene Chr1:132373983-132389891 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015452
 protein coding gene Chr1:137085075-137101460 (+)
WSB/EiJ MGP_WSBEiJ_G0015942
 protein coding gene Chr1:138141499-138157723 (+)



Homology
more
  • Human Ortholog
    TNNT2, troponin T2, cardiac type
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNNT2, troponin T2, cardiac type
  • Synonyms
    CMD1D, CMH2, CMPD2, cTnT, LVNC6, RCM3, TnTC
  • Links
    NCBI Gene ID: 7139
    neXtProt AC: NX_P45379
    UniProt: P45379

  • Chr Location
    1q32.1; chr1:201359008-201377764 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Tnnt2 mouse models; 7 with human TNNT2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 5 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    62 phenotypes from 12 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during and prior to organogenesis and abnormal heart development. Mice homozygous for an allele that lacks the lysine residue at position 210 exhibit dilated cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1223
  • Tissues
    132
  • cDNA Data
    123
  • Literature Summary
    264
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026414 Ensembl Gene Model | MGI Sequence Detail 15907 C57BL/6J ±  kb
    transcript ENSMUST00000188028 Ensembl | MGI Sequence Detail 1200 Not Applicable  
    polypeptide ENSMUSP00000140941 Ensembl | MGI Sequence Detail 302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 151
      Genomic 1
      cDNA 124
      Primer pair 19
      Other 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26031
    References
    more
    • Summaries
      All 390
      Developmental Gene Expression 264
      Diseases 6
      Gene Ontology 15
      Phenotypes 70
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:357409 Padmanabhan A, et al., A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nat Cardiovasc Res. 2024 Mar;3(3):317-331
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory