Ccr3 MGI Mouse Gene Detail - MGI:104616 - C-C motif chemokine receptor 3

Symbol

Ccr3
Name

C-C motif chemokine receptor 3
Synonyms

CC-CKR3, CKR3, Cmkbr3, MIP-1 alphaRL2

Feature Type

protein coding gene
IDs

MGI:104616
NCBI Gene: 12771
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:123822009-123831726 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 75.05 cM, cytoband F
Mapping Data

4 experiments

SNPs within 2kb

210 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104616	protein coding gene	Chr9:123817799-123831729 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035491	protein coding gene	Chr9:127135755-127146293 (+)
A/J	MGP_AJ_G0035469	protein coding gene	Chr9:122223044-122232762 (+)
AKR/J	MGP_AKRJ_G0035402	protein coding gene	Chr9:125494880-125504598 (+)
BALB/cJ	MGP_BALBcJ_G0035465	protein coding gene	Chr9:122156258-122165976 (+)
C3H/HeJ	MGP_C3HHeJ_G0035172	protein coding gene	Chr9:125945040-125960211 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035988	protein coding gene	Chr9:130590727-130605676 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032870	protein coding gene	Chr9:119280640-119290639 (+)
CAST/EiJ	MGP_CASTEiJ_G0034477	protein coding gene	Chr9:125954716-125968589 (+)
CBA/J	MGP_CBAJ_G0035140	protein coding gene	Chr9:135398381-135416052 (+)
DBA/2J	MGP_DBA2J_G0035299	protein coding gene	Chr9:121712168-121723416 (+)
FVB/NJ	MGP_FVBNJ_G0035246	protein coding gene	Chr9:120571806-120581155 (+)
LP/J	MGP_LPJ_G0035378	protein coding gene	Chr9:127500310-127517977 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035287	protein coding gene	Chr9:136190021-136218952 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036007	protein coding gene	Chr9:125984819-125994537 (+)
PWK/PhJ	MGP_PWKPhJ_G0034181	protein coding gene	Chr9:122116106-122125984 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034018	protein coding gene	Chr9:126013181-126022926 (+)
WSB/EiJ	MGP_WSBEiJ_G0034597	protein coding gene	Chr9:125773510-125785367 (+)

Human Ortholog

CCR3, C-C motif chemokine receptor 3

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCR3, C-C motif chemokine receptor 3
Synonyms

C C CKR3, CC-CKR-3, CD193, CKR 3, CKR3, CMKBR3
Links

HGNC:1604

NCBI Gene ID: 1232

neXtProt AC: NX_P51677

UniProt: P51677
Chr Location

3p21.31; chr3:46130890-46266706 (+) GRCh38

MGI Vertebrate Homology

Ccr3 stringent orthology
1 human;1 mouse;1 rat;6 zebrafish
HCOP

vertebrate homology predictions: CCR3
Gene Tree

Ccr3

Diseases

3 with human CCR3 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096
				ovary epithelial cancer IDs ovary epithelial cancer DOID:2152 NCI:C4381 UMLS_CUI:C0341823
				rhinitis IDs rhinitis DOID:4483 MESH:D012220 NCI:C34986 UMLS_CUI:C0035455

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

6
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in impaired eosinophil trafficking to the lungs and small intestine, and in increased bronchorestriction following methacholine challenge.

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

23
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ccr3

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All Sequences

37
RefSeq

4
UniProt

3
CCDS

CCDS23668.1

Ensembl

ENSMUSG00000035448 (Evidence)
NCBI Gene

12771

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035448	Ensembl Gene Model \| MGI Sequence Detail	9718	C57BL/6J	± kb
transcript	ENSMUST00000039171	Ensembl \| MGI Sequence Detail	3272	Not Applicable
polypeptide	ENSMUSP00000039107	Ensembl \| MGI Sequence Detail	359	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001255 C-C chemokine receptor type 3

(term hierarchy)
InterPro Domains

IPR002238 CC chemokine receptor 3

IPR000355 Chemokine receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 15

Genomic 2

cDNA 10

Primer pair 1

Other 2

Microarray probesets 3

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MGD-MRK-26053

Summaries

All 87

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 43
Earliest

J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
Latest

J:351986 Kim HJ, et al., TLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice. Exp Mol Med. 2024 May;56(5):1164-1177

TSS for Ccr3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87990	Chr9:123822002-123822014 (+)	-1 bp
Tssr87991	Chr9:123822147-123822160 (+)	145 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24