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Strbp Gene Detail
Summary
  • Symbol
    Strbp
  • Name
    spermatid perinuclear RNA binding protein
  • Synonyms
    6430510M02Rik, C230082I21Rik, Spnr
  • Feature Type
    protein coding gene
  • IDs
    MGI:104626
    NCBI Gene: 20744
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:37459880-37593890 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.19 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1590 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104626
 protein coding gene Chr2:37373240-37593890 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025697
 protein coding gene Chr2:36181138-36417658 (-)
A/J MGP_AJ_G0025674
 protein coding gene Chr2:34701657-34924390 (-)
AKR/J MGP_AKRJ_G0025644
 protein coding gene Chr2:35855252-36085621 (-)
BALB/cJ MGP_BALBcJ_G0025669
 protein coding gene Chr2:34763518-34985701 (-)
C3H/HeJ MGP_C3HHeJ_G0025430
 protein coding gene Chr2:35774878-36001908 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026115
 protein coding gene Chr2:37217935-37453916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023520
 protein coding gene Chr2:33377341-33591171 (-)
CAST/EiJ MGP_CASTEiJ_G0024893
 protein coding gene Chr2:35681789-35918112 (-)
CBA/J MGP_CBAJ_G0025409
 protein coding gene Chr2:38614967-38863110 (-)
DBA/2J MGP_DBA2J_G0025541
 protein coding gene Chr2:34445594-34671081 (-)
FVB/NJ MGP_FVBNJ_G0025503
 protein coding gene Chr2:34326142-34547718 (-)
LP/J MGP_LPJ_G0025628
 protein coding gene Chr2:36070017-36310348 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025534
 protein coding gene Chr2:38212321-38464057 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026173
 protein coding gene Chr2:35736476-35965122 (-)
PWK/PhJ MGP_PWKPhJ_G0024635
 protein coding gene Chr2:34339913-34569283 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024440
 protein coding gene Chr2:35846296-36084483 (-)
WSB/EiJ MGP_WSBEiJ_G0024961
 protein coding gene Chr2:35919774-36150339 (-)



Homology
more
  • Human Ortholog
    STRBP, spermatid perinuclear RNA binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STRBP, spermatid perinuclear RNA binding protein
  • Synonyms
    HEL162, ILF3L, p74, SPNR
  • Links
    NCBI Gene ID: 55342
    neXtProt AC: NX_Q96SI9
    UniProt: Q96SI9

  • Chr Location
    9q33.3; chr9:123109494-123268586 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap insertion exhibit premature death, a reduced body size and an abnormal clutching reflex. Minor brain abnormalities and spermatogenesis defects were also noted.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    35
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20744 NCBI Gene Model | MGI Sequence Detail 134011 C57BL/6J ±  kb
    transcript NM_001355259 RefSeq | MGI Sequence Detail 17333 C57BL/6  
    polypeptide Q91WM1 UniProt | EBI | MGI Sequence Detail 672 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-26063, MGI:2139088, MGI:2139526, MGI:2442183
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:25219 Schumacher JM, et al., Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. J Cell Biol. 1995 May;129(4):1023-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory